U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mgtor Megator [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36264, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Mgtorprovided by FlyBase
Official Full Name
Megatorprovided by FlyBase
Primary source
FLYBASE:FBgn0013756
Locus tag
Dmel_CG8274
See related
AllianceGenome:FB:FBgn0013756
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Bx34; CG8274; Dmel\CG8274; l(2)k03905; mtor; Mtor; MTOR; Tpr; TPR
Summary
Enables chromatin DNA binding activity and histone acetyltransferase binding activity. Involved in several processes, including regulation of mitotic nuclear division; regulation of transcription by RNA polymerase II; and spindle organization. Located in several cellular components, including euchromatin; nucleus; and spindle. Part of nuclear pore. Is expressed in adult brain cell body rind; adult head; adult optic lobe; male germline cell; and somatic cell of testis. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human TPR (translocated promoter region, nuclear basket protein). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Mgtor in Genome Data Viewer
Location:
48C5-48C5; 2-65 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11852617..11861202)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7740122..7748707)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44304 Neighboring gene uncharacterized protein Neighboring gene Silnoon Neighboring gene uncharacterized protein Neighboring gene Tweedlebeta

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. An organelle-exclusion envelope assists mitosis and underlies distinct molecular crowding in the spindle region. Schweizer N, et al. J Cell Biol, 2015 Aug 31. PMID 26304726, Free PMC Article
  2. A Drosophila Tpr protein homolog is localized both in the extrachromosomal channel network and to nuclear pore complexes. Zimowska G, et al. J Cell Sci, 1997 Apr. PMID 9152019
  3. EAST interacts with Megator and localizes to the putative spindle matrix during mitosis in Drosophila. Qi H, et al. J Cell Biochem, 2005 Aug 15. PMID 15962301
  4. Asator, a tau-tubulin kinase homolog in Drosophila localizes to the mitotic spindle. Qi H, et al. Dev Dyn, 2009 Dec. PMID 19890914
  5. The nucleoskeleton: go EAST, young man. Lasky LA. Nat Cell Biol, 2000 May. PMID 10806487

See all (107) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TGFB-INHB/activin signaling regulates age-dependent autophagy and cardiac health through inhibition of MTORC2.
    Title: TGFB-INHB/activin signaling regulates age-dependent autophagy and cardiac health through inhibition of MTORC2.
  2. mTOR-S6K1 pathway mediates cytoophidium assembly
    Title: mTOR-S6K1 pathway mediates cytoophidium assembly.
  3. Data indicate a role for ubiquilins as regulators of autophagy by controlling mTOR serine-threonine kinases (mTOR)signalling.
    Title: Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification.
  4. we demonstrate that Tpr zymogen and the ZP domain of the ECM protein Piopio are cleaved by Np and matriptase in vitro.
    Title: Conserved function of the matriptase-prostasin proteolytic cascade during epithelial morphogenesis.
  5. Data show that the spindle matrix complex, including Chromator/Chriz (Chro), Megator (Mtor), and enhanced adult sensory threshold (East), has a novel nuclear function in reactivation of neural stem cells (NSCs).
    Title: An intrinsic mechanism controls reactivation of neural stem cells by spindle matrix proteins.
  6. Mtor is required for the correct centrosome orientation, mitotic spindle formation, and chromosome segregation.
    Title: The Nuclear Matrix Protein Megator Regulates Stem Cell Asymmetric Division through the Mitotic Checkpoint Complex in Drosophila Testes.
  7. WAC promotes the interaction between TTT and Pontin/Reptin in an energy-dependent manner, thereby promoting mTORC1 activity by facilitating mTORC1 dimerization and mTORC1-Rag interaction
    Title: WAC Regulates mTOR Activity by Acting as an Adaptor for the TTT and Pontin/Reptin Complexes.
  8. Data show that the spindle matrix protein Megator requires its coiled-coil amino-terminal domain for spindle matrix localization.
    Title: A nuclear-derived proteinaceous matrix embeds the microtubule spindle apparatus during mitosis.
  9. Reduced TOR activity promotes grk translation independent of the canonical Vasa-RNA helicase and cap-dependent mechanism.
    Title: Modulation of gurken translation by insulin and TOR signaling in Drosophila.
  10. Nup153 and Megator (Mtor) bind to 25% of the genome in continuous domains extending 10 kb to 500 kb.
    Title: Nuclear pore proteins nup153 and megator define transcriptionally active regions in the Drosophila genome.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone acetyltransferase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribonucleoprotein complex binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ-line stem-cell niche homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in male germ-line stem cell asymmetric division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle assembly checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in regulation of chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of metaphase plate congression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic sister chromatid separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in regulation of mitotic spindle elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to endoplasmic reticulum stress HMP PubMed 
involved_in response to heat IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sex-chromosome dosage compensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spindle assembly IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in euchromatin IDA
Inferred from Direct Assay
more info
 PubMed 
NOT located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in metaphase plate IDA
Inferred from Direct Assay
more info
 PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with mitotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope HDA PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear inclusion body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear lamina IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear periphery IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle midzone IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
megator
Names
CG8274-PA
CG8274-PB
Mgtor-PA
Mgtor-PB
lethal (2) k03905

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    11852617..11861202
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273974.1 → NP_001260903.1  megator, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260903.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1Z8P9, O01385
    UniProtKB/TrEMBL
    A0A0B4KFE9
    Conserved Domains (5) summary
    cd00187
    Location:1398 → 1605
    TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...
    TIGR04523
    Location:177 → 911
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam07926
    Location:1031 → 1158
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09728
    Location:1201 → 1476
    Taxilin; Myosin-like coiled-coil protein
    pfam13863
    Location:833 → 915
    DUF4200; Domain of unknown function (DUF4200)

  2. NM_057719.4 → NP_477067.2  megator, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477067.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1Z8P9, O01385
    UniProtKB/TrEMBL
    A0A0B4KFE9
    Related
    FBpp0087140
    Conserved Domains (5) summary
    cd00187
    Location:1398 → 1605
    TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...
    TIGR04523
    Location:177 → 911
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam07926
    Location:1031 → 1158
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09728
    Location:1201 → 1476
    Taxilin; Myosin-like coiled-coil protein
    pfam13863
    Location:833 → 915
    DUF4200; Domain of unknown function (DUF4200)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KFE9 A0A0B4KFE9
A1Z8P9.1 A1Z8P9
Q8IGK6 Q8IGK6
Q961T0 Q961T0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous