U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Smc2 structural maintenance of chromosomes 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362519, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Smc2provided by RGD
Official Full Name
structural maintenance of chromosomes 2provided by RGD
Primary source
RGD:1305227
See related
EnsemblRapid:ENSRNOG00000022325 AllianceGenome:RGD:1305227
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CAPE; CAP-E; Smc2l1
Summary
Predicted to enable chromatin binding activity and single-stranded DNA binding activity. Predicted to be involved in mitotic chromosome condensation; positive regulation of chromosome condensation; and regulation of chromosome segregation. Predicted to act upstream of or within kinetochore organization; meiotic chromosome condensation; and meiotic chromosome segregation. Predicted to be located in chromatin; cytoplasm; and nuclear lumen. Predicted to be part of condensin complex. Predicted to be active in condensed chromosome. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human SMC2 (structural maintenance of chromosomes 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 254.2), Spleen (RPKM 192.8) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Smc2 in Genome Data Viewer
Location:
5q23
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (71592428..71648636)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (66806882..66853478)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (68717509..68764080)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL29-like Neighboring gene ribosomal protein S6, pseudogene 10 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene small nucleolar RNA SNORA17 Neighboring gene topoisomerase I binding, arginine/serine-rich like

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Diminished Condensin Gene Expression Drives Chromosome Instability That May Contribute to Colorectal Cancer Pathogenesis. Baergen AK, et al. Cancers (Basel), 2019 Jul 28. PMID 31357676, Free PMC Article
  2. Mutational and expressional analysis of SMC2 gene in gastric and colorectal cancers with microsatellite instability. Je EM, et al. APMIS, 2014 Jun. PMID 24483990
  3. Human SMC2 protein, a core subunit of human condensin complex, is a novel transcriptional target of the WNT signaling pathway and a new therapeutic target. Dávalos V, et al. J Biol Chem, 2012 Dec 21. PMID 23095742, Free PMC Article
  4. Structure and DNA binding activity of the mouse condensin hinge domain highlight common and diverse features of SMC proteins. Griese JJ, et al. Nucleic Acids Res, 2010 Jun. PMID 20139420, Free PMC Article
  5. A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation. Schmiesing JA, et al. Mol Cell Biol, 2000 Sep. PMID 10958694, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Demonstrates that the human Smc2l1 ortholog, hCAP-E, is a member of the condensin complex that is involved in mitotic chromosome condensation.
    Title: A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within kinetochore organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within meiotic chromosome condensation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within meiotic chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic chromosome condensation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of chromosome condensation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of chromosome separation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in condensed chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in condensed chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in condensed nuclear chromosome ISO
Inferred from Sequence Orthology
more info
  
part_of condensin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of condensin complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
structural maintenance of chromosomes protein 2
Names
SMC2 structural maintenance of chromosomes 2-like 1
chromosome-associated protein E

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108666.3 → NP_001102136.2  structural maintenance of chromosomes protein 2

    See identical proteins and their annotated locations for NP_001102136.2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    D4A5Q2
    Related
    ENSRNOP00000061673.1, ENSRNOT00000066226.4
    Conserved Domains (7) summary
    pfam06673
    Location:252 → 465
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    cd03273
    Location:1 → 172
    ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
    smart00968
    Location:522 → 639
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:1 → 1168
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:740 → 841
    DUF4200; Domain of unknown function (DUF4200)
    cl21455
    Location:1074 → 1168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl23943
    Location:693 → 761
    PCRF; PCRF domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    71592428..71648636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238165.5 → XP_006238227.1  structural maintenance of chromosomes protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006238227.1

    UniProtKB/TrEMBL
    D4A5Q2
    Conserved Domains (7) summary
    pfam06673
    Location:252 → 465
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    cd03273
    Location:1 → 172
    ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
    smart00968
    Location:522 → 639
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:1 → 1168
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:740 → 841
    DUF4200; Domain of unknown function (DUF4200)
    cl21455
    Location:1074 → 1168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl23943
    Location:693 → 761
    PCRF; PCRF domain

  2. XM_063287920.1 → XP_063143990.1  structural maintenance of chromosomes protein 2 isoform X1

    UniProtKB/TrEMBL
    D4A5Q2
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous