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Dctn3 dynactin subunit 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362504, updated on 4-Jan-2025

Summary

Official Symbol
Dctn3provided by RGD
Official Full Name
dynactin subunit 3provided by RGD
Primary source
RGD:1309547
See related
EnsemblRapid:ENSRNOG00000014208 AllianceGenome:RGD:1309547
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in cytoskeleton-dependent cytokinesis. Predicted to act upstream of or within microtubule-based process. Located in microtubule. Part of dynactin complex. Orthologous to human DCTN3 (dynactin subunit 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 215.0), Kidney (RPKM 192.1) and 9 other tissues See more
Orthologs
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Genomic context

See Dctn3 in Genome Data Viewer
Location:
5q22
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (61676950..61684958, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (56881085..56889041, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (58098706..58106706, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ciliary neurotrophic factor receptor Neighboring gene ribonuclease P/MRP subunit p25 like Neighboring gene AT-rich interaction domain 3C Neighboring gene sigma non-opioid intracellular receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cytoskeleton-dependent cytokinesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within microtubule-based process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of dynactin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of dynactin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of dynactin complex ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule IDA
Inferred from Direct Assay
more info
PubMed 
part_of microtubule associated complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dynactin subunit 3
Names
dynactin 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108659.1NP_001102129.1  dynactin subunit 3

    See identical proteins and their annotated locations for NP_001102129.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473962
    UniProtKB/TrEMBL
    A6IIW6, D4A1B8
    Conserved Domains (1) summary
    pfam07426
    Location:10170
    Dynactin_p22; Dynactin subunit p22

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    61676950..61684958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287902.1XP_063143972.1  dynactin subunit 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ACK1
    Related
    ENSRNOP00000089767.1, ENSRNOT00000114254.2