Ripk2 receptor-interacting serine-threonine kinase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ripk2provided by RGD
Official Full Name: receptor-interacting serine-threonine kinase 2provided by RGD
Primary source: RGD:1309167
See related: EnsemblRapid:ENSRNOG00000009389 AllianceGenome:RGD:1309167
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including JUN kinase kinase kinase activity; caspase binding activity; and protein domain specific binding activity. Predicted to be involved in several processes, including defense response to other organism; intracellular signaling cassette; and positive regulation of protein metabolic process. Predicted to act upstream of or within several processes, including positive regulation of cytokine production; positive regulation of immune response; and response to bacterium. Predicted to be located in cytoskeleton; cytosol; and vesicle. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human RIPK2 (receptor interacting serine/threonine kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 72.0), Spleen (RPKM 64.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q13

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (34428573..34459808, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (29630806..29662804, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (29838713..29870390, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LACC1 Promoted Nerve Injury in an Anesthesia-Induced Cognitive Disorder Model via RIP2 Expression through ROS-NOD2 Induction.
Title: LACC1 Promoted Nerve Injury in an Anesthesia-Induced Cognitive Disorder Model via RIP2 Expression through ROS-NOD2 Induction.
Blocking RIPK2 Function Alleviates Myocardial Ischemia/Reperfusion Injury by Regulating the AKT and NF-kappaB Pathways.
Title: Blocking RIPK2 Function Alleviates Myocardial Ischemia/Reperfusion Injury by Regulating the AKT and NF-κB Pathways.
Receptor-interacting serine-threonine kinase 2 (RIP2) tends to form high-order oligomers at physiological pH while being monomeric under acidic conditions.
Title: CARD domain of rat RIP2 kinase: Refolding, solution structure, pH-dependent behavior and protein-protein interactions.
combined results support the hypothesis that high glucose and LPS can activate the NOD1-RICK-NF-kappaB inflammatory signaling pathway via the NOD1 receptor, and may participate in the development of diabetic nephropathy.
Title: High Glucose and Lipopolysaccharide Activate NOD1- RICK-NF-κB Inflammatory Signaling in Mesangial Cells.
Nod2-Rip2-NFkappaB signaling involved in the small intestinal inflammatory injury caused by muramyl dipeptide which is transported through PepT1.
Title: Nod2-Rip2 Signaling Contributes to Intestinal Injury Induced by Muramyl Dipeptide Via Oligopeptide Transporter in Rats.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables CARD domain binding	ISO Inferred from Sequence Orthology more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables JUN kinase kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables LIM domain binding	ISO Inferred from Sequence Orthology more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables caspase binding	ISO Inferred from Sequence Orthology more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of CD4-positive, alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of JNK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in activation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in adaptive immune response	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to lipoteichoic acid	ISO Inferred from Sequence Orthology more info
involved_in cellular response to muramyl dipeptide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to peptidoglycan	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of immature T cell proliferation in thymus	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nucleotide-binding oligomerization domain containing 1 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in nucleotide-binding oligomerization domain containing 1 signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nucleotide-binding oligomerization domain containing 2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of CD4-positive, alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T-helper 1 cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T-helper 1 type immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of immature T cell proliferation in thymus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of macrophage cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of xenophagy	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to exogenous dsRNA	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to interleukin-1	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to interleukin-12	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to interleukin-18	ISO Inferred from Sequence Orthology more info
acts_upstream_of stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within toll-like receptor 2 signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of xenophagy	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: receptor-interacting serine/threonine-protein kinase 2

Names: receptor (TNFRSF)-interacting serine-threonine kinase 2

NP_001178794.1

EC 2.7.11.1

XP_017448959.1

EC 2.7.11.1

XP_038966149.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191865.1 → NP_001178794.1 receptor-interacting serine/threonine-protein kinase 2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A6IIB5, G3V783

Related

ENSRNOP00000012963.2, ENSRNOT00000012963.7

Conserved Domains (3) summary

cd08786
Location:437 → 523

CARD_RIP2_CARD3; Caspase activation and recruitment domain of Receptor Interacting Protein 2

smart00221
Location:21 → 290

STYKc; Protein kinase; unclassified specificity

cd14026
Location:20 → 303

STKc_RIP2; Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

34428573..34459808 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017593470.3 → XP_017448959.1 receptor-interacting serine/threonine-protein kinase 2 isoform X1

UniProtKB/TrEMBL

Q3B7U0
XM_039110221.2 → XP_038966149.1 receptor-interacting serine/threonine-protein kinase 2 isoform X2

UniProtKB/TrEMBL

Q3B7U0

Conserved Domains (2) summary

cd08786
Location:300 → 386

CARD_RIP2_CARD3; Caspase activation and recruitment domain of Receptor Interacting Protein 2

cl21453
Location:1 → 166

PKc_like; Protein Kinases, catalytic domain