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Mical3 microtubule associated monooxygenase, calponin and LIM domain containing 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362427, updated on 27-Nov-2024

Summary

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Symbol
Mical3provided by RGD
Full Name
microtubule associated monooxygenase, calponin and LIM domain containing 3provided by RGD
Primary source
RGD:1359504
See related
EnsemblRapid:ENSRNOG00000053203 AllianceGenome:RGD:1359504
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin binding activity and molecular adaptor activity. Predicted to be involved in actin filament depolymerization. Predicted to be located in several cellular components, including Flemming body; intercellular bridge; and nucleoplasm. Orthologous to human MICAL3 (microtubule associated monooxygenase, calponin and LIM domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 150.3), Uterus (RPKM 116.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mical3 in Genome Data Viewer
Location:
4q42
Exon count:
56
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (155824941..156025003, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (154152776..154353274, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (153484876..153631986, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene Bcl2-like 13 Neighboring gene BH3 interacting domain death agonist Neighboring gene uncharacterized LOC134486634 Neighboring gene uncharacterized LOC134486633 Neighboring gene uncharacterized LOC134486635 Neighboring gene peroxisomal biogenesis factor 26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the rat. Pasterkamp RJ, et al. Mol Cell Neurosci, 2006 Jan. PMID 16230022
  2. The MICAL proteins and rab1: a possible link to the cytoskeleton? Fischer J, et al. Biochem Biophys Res Commun, 2005 Mar 11. PMID 15694364
  3. Redox modification of nuclear actin by MICAL-2 regulates SRF signaling. Lundquist MR, et al. Cell, 2014 Jan 30. PMID 24440334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tesults implicate MICALs in neuronal regeneration and support the possibility to attenuate axon repulsion in the injured spinal cord.
    Title: MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the rat.
  2. Using the microtubule depolymerizing drug nocodazole we detected a link between MICAL-1 and -3, and the microtubule cytoskeleton.
    Title: The MICAL proteins and rab1: a possible link to the cytoskeleton?
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables F-actin monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Flemming body IEA
Inferred from Electronic Annotation
more info
  
located_in Flemming body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
F-actin-monooxygenase MICAL3
Names
flavoprotein oxidoreductase MICAL3
microtubule associated monoxygenase, calponin and LIM domain containing 3
protein MICAL-3
protein-methionine sulfoxide oxidase MICAL3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191085.4 → NP_001178014.2  F-actin-monooxygenase MICAL3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I6AA21, D3ZGN7
    Conserved Domains (5) summary
    cd09439
    Location:764 → 818
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam05109
    Location:1114 → 1507
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01494
    Location:87 → 274
    FAD_binding_3; FAD binding domain
    pfam12130
    Location:1849 → 1978
    DUF3585; Protein of unknown function (DUF3585)
    cd21251
    Location:515 → 625
    CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

  2. NM_001415882.2 → NP_001402811.1  F-actin-monooxygenase MICAL3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    D3ZGN7
    Related
    ENSRNOP00000072316.2, ENSRNOT00000082982.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    155824941..156025003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107870.2 → XP_038963798.1  F-actin-monooxygenase MICAL3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A4K7
    Conserved Domains (5) summary
    cd09439
    Location:916 → 970
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam05109
    Location:1336 → 1729
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01494
    Location:87 → 274
    FAD_binding_3; FAD binding domain
    pfam12130
    Location:2088 → 2256
    DUF3585; Protein of unknown function (DUF3585)
    cd21251
    Location:515 → 625
    CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

  2. XM_039107872.2 → XP_038963800.1  F-actin-monooxygenase MICAL3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A4K7
    Conserved Domains (5) summary
    cd09439
    Location:916 → 970
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam05109
    Location:1336 → 1729
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01494
    Location:87 → 274
    FAD_binding_3; FAD binding domain
    pfam12130
    Location:2088 → 2256
    DUF3585; Protein of unknown function (DUF3585)
    cd21251
    Location:515 → 625
    CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

  3. XM_063286323.1 → XP_063142393.1  F-actin-monooxygenase MICAL3 isoform X14

  4. XM_039107884.2 → XP_038963812.1  F-actin-monooxygenase MICAL3 isoform X13

    UniProtKB/TrEMBL
    A0A8I5Y064
    Related
    ENSRNOP00000076562.1, ENSRNOT00000110199.2
    Conserved Domains (5) summary
    cd09439
    Location:764 → 818
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam05109
    Location:1165 → 1558
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01494
    Location:87 → 274
    FAD_binding_3; FAD binding domain
    pfam12130
    Location:1917 → 2085
    DUF3585; Protein of unknown function (DUF3585)
    cd21251
    Location:515 → 625
    CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

  5. XM_039107882.2 → XP_038963810.1  F-actin-monooxygenase MICAL3 isoform X12

    UniProtKB/TrEMBL
    A0A8I5Y064
    Conserved Domains (5) summary
    cd09439
    Location:764 → 818
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam05109
    Location:1184 → 1577
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01494
    Location:87 → 274
    FAD_binding_3; FAD binding domain
    pfam12130
    Location:1936 → 2104
    DUF3585; Protein of unknown function (DUF3585)
    cd21251
    Location:515 → 625
    CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

  6. XM_039107876.2 → XP_038963804.1  F-actin-monooxygenase MICAL3 isoform X5

    UniProtKB/TrEMBL
    A0A8I6A4K7
    Conserved Domains (5) summary
    cd09439
    Location:916 → 970
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam05109
    Location:1317 → 1710
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01494
    Location:87 → 274
    FAD_binding_3; FAD binding domain
    pfam12130
    Location:2069 → 2237
    DUF3585; Protein of unknown function (DUF3585)
    cd21251
    Location:515 → 625
    CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

  7. XM_039107873.2 → XP_038963801.1  F-actin-monooxygenase MICAL3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A4K7
    Conserved Domains (5) summary
    cd09439
    Location:916 → 970
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam05109
    Location:1335 → 1728
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01494
    Location:87 → 274
    FAD_binding_3; FAD binding domain
    pfam12130
    Location:2087 → 2255
    DUF3585; Protein of unknown function (DUF3585)
    cd21251
    Location:515 → 625
    CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

  8. XM_039107881.2 → XP_038963809.1  F-actin-monooxygenase MICAL3 isoform X11

    UniProtKB/TrEMBL
    A0A8I6A4K7
    Related
    ENSRNOP00000101630.1, ENSRNOT00000146641.1
    Conserved Domains (5) summary
    cd09439
    Location:916 → 970
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam05109
    Location:1260 → 1653
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01494
    Location:87 → 274
    FAD_binding_3; FAD binding domain
    pfam12130
    Location:2012 → 2180
    DUF3585; Protein of unknown function (DUF3585)
    cd21251
    Location:515 → 625
    CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

  9. XM_039107877.2 → XP_038963805.1  F-actin-monooxygenase MICAL3 isoform X6

    UniProtKB/TrEMBL
    A0A8I6A4K7
    Conserved Domains (5) summary
    cd09439
    Location:916 → 970
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam05109
    Location:1315 → 1708
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01494
    Location:87 → 274
    FAD_binding_3; FAD binding domain
    pfam12130
    Location:2067 → 2235
    DUF3585; Protein of unknown function (DUF3585)
    cd21251
    Location:515 → 625
    CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

  10. XM_063286322.1 → XP_063142392.1  F-actin-monooxygenase MICAL3 isoform X10

    Related
    ENSRNOP00000087542.2, ENSRNOT00000104269.2

  11. XM_039107879.2 → XP_038963807.1  F-actin-monooxygenase MICAL3 isoform X8

    UniProtKB/TrEMBL
    A0A8I6A4K7
    Conserved Domains (5) summary
    cd09439
    Location:916 → 970
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam05109
    Location:1336 → 1729
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01494
    Location:87 → 274
    FAD_binding_3; FAD binding domain
    pfam12130
    Location:2071 → 2217
    DUF3585; Protein of unknown function (DUF3585)
    cd21251
    Location:515 → 625
    CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

  12. XM_039107874.2 → XP_038963802.1  F-actin-monooxygenase MICAL3 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A4K7
    Conserved Domains (5) summary
    cd09439
    Location:916 → 970
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam05109
    Location:1336 → 1729
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01494
    Location:87 → 274
    FAD_binding_3; FAD binding domain
    pfam12130
    Location:2071 → 2239
    DUF3585; Protein of unknown function (DUF3585)
    cd21251
    Location:515 → 625
    CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

  13. XM_039107880.2 → XP_038963808.1  F-actin-monooxygenase MICAL3 isoform X9

    UniProtKB/TrEMBL
    A0A8I6A4K7
    Conserved Domains (5) summary
    cd09439
    Location:916 → 970
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam05109
    Location:1336 → 1729
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01494
    Location:87 → 274
    FAD_binding_3; FAD binding domain
    pfam12130
    Location:2088 → 2217
    DUF3585; Protein of unknown function (DUF3585)
    cd21251
    Location:515 → 625
    CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

  14. XM_039107875.2 → XP_038963803.1  F-actin-monooxygenase MICAL3 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A4K7
    Conserved Domains (5) summary
    cd09439
    Location:916 → 970
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam05109
    Location:1336 → 1729
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01494
    Location:87 → 274
    FAD_binding_3; FAD binding domain
    pfam12130
    Location:2088 → 2239
    DUF3585; Protein of unknown function (DUF3585)
    cd21251
    Location:515 → 625
    CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

  15. XM_039107878.2 → XP_038963806.1  F-actin-monooxygenase MICAL3 isoform X7

    UniProtKB/TrEMBL
    A0A8I6A4K7
    Conserved Domains (5) summary
    cd09439
    Location:916 → 970
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam05109
    Location:1336 → 1729
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01494
    Location:87 → 274
    FAD_binding_3; FAD binding domain
    pfam12130
    Location:2088 → 2234
    DUF3585; Protein of unknown function (DUF3585)
    cd21251
    Location:515 → 625
    CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

  16. XM_039107869.2 → XP_038963797.1  F-actin-monooxygenase MICAL3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A4K7
    Conserved Domains (5) summary
    cd09439
    Location:916 → 970
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam05109
    Location:1336 → 1729
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01494
    Location:87 → 274
    FAD_binding_3; FAD binding domain
    pfam12130
    Location:2088 → 2256
    DUF3585; Protein of unknown function (DUF3585)
    cd21251
    Location:515 → 625
    CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

  17. XM_063286321.1 → XP_063142391.1  F-actin-monooxygenase MICAL3 isoform X1

  18. XM_039107871.2 → XP_038963799.1  F-actin-monooxygenase MICAL3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A4K7
    Conserved Domains (5) summary
    cd09439
    Location:916 → 970
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam05109
    Location:1336 → 1729
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01494
    Location:87 → 274
    FAD_binding_3; FAD binding domain
    pfam12130
    Location:2088 → 2256
    DUF3585; Protein of unknown function (DUF3585)
    cd21251
    Location:515 → 625
    CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

  19. XM_063286324.1 → XP_063142394.1  F-actin-monooxygenase MICAL3 isoform X15

  20. XM_039107886.2 → XP_038963814.1  F-actin-monooxygenase MICAL3 isoform X16

    Conserved Domains (3) summary
    cd09439
    Location:290 → 344
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam05109
    Location:710 → 1103
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam12130
    Location:1462 → 1630
    DUF3585; Protein of unknown function (DUF3585)

  21. XM_063286327.1 → XP_063142397.1  F-actin-monooxygenase MICAL3 isoform X20

  22. XM_063286326.1 → XP_063142396.1  F-actin-monooxygenase MICAL3 isoform X19

  23. XM_063286325.1 → XP_063142395.1  F-actin-monooxygenase MICAL3 isoform X18

  24. XM_039107887.2 → XP_038963815.1  F-actin-monooxygenase MICAL3 isoform X17

    Conserved Domains (3) summary
    cd09439
    Location:916 → 970
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam01494
    Location:87 → 274
    FAD_binding_3; FAD binding domain
    cd21251
    Location:515 → 625
    CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

  25. XM_063286328.1 → XP_063142398.1  F-actin-monooxygenase MICAL3 isoform X22

  26. XM_063286330.1 → XP_063142400.1  F-actin-monooxygenase MICAL3 isoform X23

  27. XM_063286329.1 → XP_063142399.1  F-actin-monooxygenase MICAL3 isoform X23

  28. XM_039107888.2 → XP_038963816.1  F-actin-monooxygenase MICAL3 isoform X21

    Conserved Domains (3) summary
    cd09439
    Location:916 → 970
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam01494
    Location:87 → 274
    FAD_binding_3; FAD binding domain
    cd21251
    Location:515 → 625
    CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

  29. XM_063286332.1 → XP_063142402.1  F-actin-monooxygenase MICAL3 isoform X24

  30. XM_063286331.1 → XP_063142401.1  F-actin-monooxygenase MICAL3 isoform X24

  31. XM_063286334.1 → XP_063142404.1  F-actin-monooxygenase MICAL3 isoform X25

  32. XM_063286333.1 → XP_063142403.1  F-actin-monooxygenase MICAL3 isoform X25

  33. XM_063286335.1 → XP_063142405.1  F-actin-monooxygenase MICAL3 isoform X25

RNA

  1. XR_010065679.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001014189.1: Suppressed sequence

    Description
    NM_001014189.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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