U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tamm41 TAM41 mitochondrial translocator assembly and maintenance homolog [ Rattus norvegicus (Norway rat) ]

Gene ID: 362419, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Symbol
Tamm41provided by RGD
Full Name
TAM41 mitochondrial translocator assembly and maintenance homologprovided by RGD
Primary source
RGD:1586150
See related
EnsemblRapid:ENSRNOG00000007874 AllianceGenome:RGD:1586150
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
TAM41
Summary
Enables phosphatidate cytidylyltransferase activity. Predicted to be involved in CDP-diacylglycerol biosynthetic process and cardiolipin biosynthetic process. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 56. Orthologous to human TAMM41 (TAM41 mitochondrial translocator assembly and maintenance homolog). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 90.3), Spleen (RPKM 69.4) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Tamm41 in Genome Data Viewer
Location:
4q42
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (149743216..149776388, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (148070388..148103728, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (146922085..146954159, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102368 Neighboring gene autophagy related 7 Neighboring gene uncharacterized LOC120102369 Neighboring gene vestigial-like family member 4 Neighboring gene mth938 domain-containing protein-like Neighboring gene endothelial differentiation-related factor 1, pseudogene 2 Neighboring gene synapsin II Neighboring gene tubulin, alpha 1B, pseudogene 4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mitochondrial CDP-diacylglycerol synthase activity is due to the peripheral protein, TAMM41 and not due to the integral membrane protein, CDP-diacylglycerol synthase 1. Blunsom NJ, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2018 Mar. PMID 29253589, Free PMC Article
  2. Metabolism and function of mitochondrial cardiolipin. Ren M, et al. Prog Lipid Res, 2014 Jul. PMID 24769127
  3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  4. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CDS activity present in mitochondria is mainly due to TAMM41, which is required for normal mitochondrial function.
    Title: Mitochondrial CDP-diacylglycerol synthase activity is due to the peripheral protein, TAMM41 and not due to the integral membrane protein, CDP-diacylglycerol synthase 1.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidate cytidylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidate cytidylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in CDP-diacylglycerol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cardiolipin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
phosphatidate cytidylyltransferase, mitochondrial
Names
CDP-DAG synthase
CDP-diacylglycerol synthase
MMP37-like protein, mitochondrial
TAM41, mitochondrial translocator assembly and maintenance protein, homolog
mitochondrial translocator assembly and maintenance protein 41 homolog
NP_001102112.1
XP_038963787.1
XP_038963788.1
XP_038963789.2
XP_063142375.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108642.1 → NP_001102112.1  phosphatidate cytidylyltransferase, mitochondrial

    See identical proteins and their annotated locations for NP_001102112.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473964
    UniProtKB/Swiss-Prot
    D3ZKT0
    Related
    ENSRNOP00000102152.1, ENSRNOT00000166481.1
    Conserved Domains (1) summary
    pfam09139
    Location:13 → 327
    Mmp37; Mitochondrial matrix Mmp37

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    149743216..149776388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107859.2 → XP_038963787.1  phosphatidate cytidylyltransferase, mitochondrial isoform X2

    Conserved Domains (1) summary
    pfam09139
    Location:13 → 312
    Mmp37; Mitochondrial matrix Mmp37

  2. XM_063286305.1 → XP_063142375.1  phosphatidate cytidylyltransferase, mitochondrial isoform X1

  3. XM_039107861.2 → XP_038963789.2  phosphatidate cytidylyltransferase, mitochondrial isoform X4

  4. XM_039107860.2 → XP_038963788.1  phosphatidate cytidylyltransferase, mitochondrial isoform X3

    Conserved Domains (1) summary
    pfam09139
    Location:13 → 188
    Mmp37; Mitochondrial matrix Mmp37

RNA

  1. XR_005503260.2 RNA Sequence

    Related
    ENSRNOT00000136613.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZKT0.1 GenPept UniProtKB/Swiss-Prot:D3ZKT0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools