E(Pc) Enhancer of Polycomb [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: E(Pc)provided by FlyBase
Official Full Name: Enhancer of Polycombprovided by FlyBase
Primary source: FLYBASE:FBgn0000581
Locus tag: Dmel_CG7776
See related: AllianceGenome:FB:FBgn0000581
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-48Ac; CG7776; Dmel\CG7776; e(pc); e(Pc); E(pc); E(PC); EN2-2; GH05739; GH14582; III; l(2)28-28-12
Summary: Involved in chromatin organization and dendrite guidance. Located in nucleus and polytene chromosome. Part of NuA4 histone acetyltransferase complex. Is expressed in optic lobe neuroepithelial cell; organism; and presumptive embryonic/larval central nervous system. Orthologous to several human genes including EPC1 (enhancer of polycomb homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 47F13-47F15; 2-64 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (11452043..11465270)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (7339548..7352775)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

esc and E(Pc) mutants enhance homologous recombination by modulating the histone acetylation status of histone H4 at the double-strand break
Title: Mutations in the extra sex combs and Enhancer of Polycomb genes increase homologous recombination in somatic cells of Drosophila melanogaster.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
involved_in chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of NuA4 histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of NuA4 histone acetyltransferase complex	IEA Inferred from Electronic Annotation more info
part_of histone acetyltransferase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of piccolo histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: enhancer of polycomb

Names: CG7776-PA; CG7776-PB; CG7776-PC; CG7776-PD; CG7776-PE; E(Pc)-PA; E(Pc)-PB; E(Pc)-PC; E(Pc)-PD; E(Pc)-PE; enhancer of NA9 2-2; transcript group III

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

11452043..11465270

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273968.1 → NP_001260897.1 enhancer of polycomb, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260897.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KFP2, O96542

Conserved Domains (1) summary

pfam10513
Location:7 → 139

EPL1; Enhancer of polycomb-like
NM_001273967.1 → NP_001260896.1 enhancer of polycomb, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260896.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KET9, O96542

Conserved Domains (1) summary

pfam10513
Location:7 → 139

EPL1; Enhancer of polycomb-like
NM_078974.3 → NP_523698.2 enhancer of polycomb, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523698.2

Status: REVIEWED

UniProtKB/TrEMBL

O96542, Q0E9C2

Related

FBpp0087238

Conserved Domains (1) summary

pfam10513
Location:7 → 139

EPL1; Enhancer of polycomb-like
NM_001273966.2 → NP_001260895.1 enhancer of polycomb, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260895.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KEK1, O96542

Conserved Domains (1) summary

pfam10513
Location:7 → 139

EPL1; Enhancer of polycomb-like
NM_165836.3 → NP_725054.1 enhancer of polycomb, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725054.1

Status: REVIEWED

UniProtKB/TrEMBL

O96542, Q0E9C2

Related

FBpp0087239

Conserved Domains (1) summary

pfam10513
Location:7 → 139

EPL1; Enhancer of polycomb-like

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0B4KEK1		A0A0B4KEK1
A0A0B4KET9		A0A0B4KET9
A0A0B4KFP2		A0A0B4KFP2
O96542		O96542
Q0E9C2		Q0E9C2
Q8MRN0		Q8MRN0
Q95TF0		Q95TF0