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Herc3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362377, updated on 4-Jan-2025

Summary

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Official Symbol
Herc3provided by RGD
Official Full Name
HECT and RLD domain containing E3 ubiquitin protein ligase 3provided by RGD
Primary source
RGD:1307803
See related
EnsemblRapid:ENSRNOG00000007304 AllianceGenome:RGD:1307803
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm. Orthologous to human HERC3 (HECT and RLD domain containing E3 ubiquitin protein ligase 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 167.1), Muscle (RPKM 121.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Herc3 in Genome Data Viewer
Location:
4q24
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (89282374..89372656)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (87952202..88042492)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (89078670..89169150)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486585 Neighboring gene peptidylprolyl isomerase D, pseudogene 16 Neighboring gene uncharacterized LOC120102287 Neighboring gene nucleosome assembly protein 1-like 5 Neighboring gene family with sequence similarity 13, member A Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable E3 ubiquitin-protein ligase HERC3
Names
hect domain and RLD 3
NP_001102101.1
XP_006236646.1
XP_006236647.1
XP_063142349.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108631.1 → NP_001102101.1  probable E3 ubiquitin-protein ligase HERC3

    See identical proteins and their annotated locations for NP_001102101.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474011
    UniProtKB/TrEMBL
    A0A0G2K5Y2, A6K140, D3ZPP6
    Related
    ENSRNOP00000010241.4, ENSRNOT00000010241.7
    Conserved Domains (3) summary
    COG5184
    Location:2 → 331
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:702 → 1048
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:313 → 377
    RCC1; Regulator of chromosome condensation (RCC1) repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    89282374..89372656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286279.1 → XP_063142349.1  probable E3 ubiquitin-protein ligase HERC3 isoform X3

  2. XM_006236585.5 → XP_006236647.1  probable E3 ubiquitin-protein ligase HERC3 isoform X2

    UniProtKB/TrEMBL
    A6K142
    Conserved Domains (4) summary
    COG5021
    Location:420 → 886
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    COG5184
    Location:2 → 331
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    pfam00415
    Location:313 → 377
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    cl27008
    Location:702 → 886
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  3. XM_006236584.4 → XP_006236646.1  probable E3 ubiquitin-protein ligase HERC3 isoform X1

    See identical proteins and their annotated locations for XP_006236646.1

    UniProtKB/TrEMBL
    A0A0G2K5Y2, A6K140, D3ZPP6
    Conserved Domains (3) summary
    COG5184
    Location:2 → 331
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:702 → 1048
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:313 → 377
    RCC1; Regulator of chromosome condensation (RCC1) repeat

RNA

  1. XR_005503255.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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