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Drip drip [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36236, updated on 2-Nov-2024

Summary

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Official Symbol
Dripprovided by FlyBase
Official Full Name
dripprovided by FlyBase
Primary source
FLYBASE:FBgn0015872
Locus tag
Dmel_CG9023
See related
AllianceGenome:FB:FBgn0015872
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-48Aa; CG9023; Dmel\CG9023; drip; DRIP; I
Summary
Enables water channel activity. Involved in renal water homeostasis; transmembrane transport; and water transport. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including Malpighian tubule Type II cell; adult head; embryonic/larval gut; embryonic/larval pharynx; and posterior spiracle primordium. Human ortholog(s) of this gene implicated in several diseases, including Bothnian type palmoplantar keratoderma; cataract (multiple); nephrogenic diabetes insipidus (multiple); optic nerve disease (multiple); and transverse myelitis. Orthologous to several human genes including AQP1 (aquaporin 1 (Colton blood group)) and AQP2 (aquaporin 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See Drip in Genome Data Viewer
Location:
47F11-47F11; 2-64 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11411203..11429645, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7298708..7317150, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43771 Neighboring gene prip

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ageing and genetic background influence anaesthetic effects in a D. melanogaster model of blunt trauma with brain injury(†). Schiffman HJ, et al. Br J Anaesth, 2020 Jul. PMID 32466842, Free PMC Article
  2. Ecdysone signaling is required for proper organization and fluid secretion of stellate cells in the Malpighian tubules of Drosophila melanogaster. Gautam NK, et al. Int J Dev Biol, 2010. PMID 20209436
  3. High sucrose diet induces morphological, structural and functional impairments in the renal tubules of Drosophila melanogaster: A model for studying type-2 diabetes mediated renal tubular dysfunction. Rani L, et al. Insect Biochem Mol Biol, 2020 Oct. PMID 32735915
  4. SIK3 suppresses neuronal hyperexcitability by regulating the glial capacity to buffer K(+) and water. Li H, et al. J Cell Biol, 2019 Dec 2. PMID 31645458, Free PMC Article
  5. Chloride channels in stellate cells are essential for uniquely high secretion rates in neuropeptide-stimulated Drosophila diuresis. Cabrero P, et al. Proc Natl Acad Sci U S A, 2014 Sep 30. PMID 25228763, Free PMC Article

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables channel activity IEA
Inferred from Electronic Annotation
more info
  
enables water channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables water channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables water channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in multicellular organismal-level water homeostasis IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in renal water homeostasis IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in water transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in water transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
drip
Names
CG9023-PA
CG9023-PB
CG9023-PC
CG9023-PD
CG9023-PE
CG9023-PF
CG9023-PG
Drip-PA
Drip-PB
Drip-PC
Drip-PD
Drip-PE
Drip-PF
Drip-PG
aquaporin
drosophila integral protein
transcript group I

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    11411203..11429645 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299387.1 → NP_001286316.1  drip, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286316.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LG55
    Conserved Domains (1) summary
    cl00200
    Location:23 → 227
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

  2. NM_001273964.1 → NP_001260893.1  drip, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260893.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFD6
    Conserved Domains (1) summary
    cl00200
    Location:23 → 227
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

  3. NM_078973.3 → NP_523697.1  drip, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523697.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24148, Q3KN56, Q8MKY6, Q9V5Z7
    UniProtKB/TrEMBL
    H6V591
    Related
    FBpp0087241
    Conserved Domains (1) summary
    cl00200
    Location:23 → 227
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

  4. NM_165833.3 → NP_725051.2  drip, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725051.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24148, Q3KN56, Q8MKY6, Q9V5Z7
    UniProtKB/TrEMBL
    H6V591
    Related
    FBpp0087240
    Conserved Domains (1) summary
    cl00200
    Location:23 → 227
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

  5. NM_001273963.1 → NP_001260892.1  drip, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260892.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFN8
    Conserved Domains (1) summary
    cl00200
    Location:17 → 221
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

  6. NM_001273961.1 → NP_001260890.1  drip, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260890.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F3YDC9
    Conserved Domains (1) summary
    cl00200
    Location:21 → 225
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

  7. NM_001273962.1 → NP_001260891.1  drip, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260891.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KET4
    Conserved Domains (1) summary
    cl00200
    Location:20 → 224
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KET4 A0A0B4KET4
A0A0B4KFD6 A0A0B4KFD6
A0A0B4KFN8 A0A0B4KFN8
A0A0B4LG55 A0A0B4LG55
F3YDC9 F3YDC9
Q9V5Z7.2 Q9V5Z7

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