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CG30022 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36233, updated on 9-Dec-2024

Summary

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Official Symbol
CG30022provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0050022
Locus tag
Dmel_CG30022
See related
AllianceGenome:FB:FBgn0050022
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE56416; CG9026; Dmel\CG30022
Summary
Predicted to enable iron ion binding activity and sulfur dioxygenase activity. Predicted to be involved in glutathione metabolic process and hydrogen sulfide metabolic process. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Used to study ethylmalonic encephalopathy. Human ortholog(s) of this gene implicated in ethylmalonic encephalopathy. Orthologous to human ETHE1 (ETHE1 persulfide dioxygenase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG30022 in Genome Data Viewer
Location:
47F8-47F8; 2-64 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11387160..11388779, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7274665..7276284, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Tetraspanin 47F Neighboring gene Superoxide dismutase 3 Neighboring gene sprite Neighboring gene transfer RNA:Threonine-TGT 2-1 Neighboring gene transfer RNA:Threonine-TGT 2-2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identifying potential dietary treatments for inherited metabolic disorders using Drosophila nutrigenomics. Martelli F, et al. Cell Rep, 2024 Mar 26. PMID 38416643, Free PMC Article
  2. Identification of conserved transcriptome features between humans and Drosophila in the aging brain utilizing machine learning on combined data from the NIH Sequence Read Archive. Webb JL, et al. PLoS One, 2021. PMID 34379632, Free PMC Article
  3. Drosophila as a diet discovery tool for treating amino acid disorders. Mele S, et al. Trends Endocrinol Metab, 2023 Feb. PMID 36567227
  4. Genomewide analysis of Drosophila GAGA factor target genes reveals context-dependent DNA binding. van Steensel B, et al. Proc Natl Acad Sci U S A, 2003 Mar 4. PMID 12601174, Free PMC Article
  5. Spitz from the retina regulates genes transcribed in the second mitotic wave, peripodial epithelium, glia and plasmatocytes of the Drosophila eye imaginal disc. Firth LC, et al. Dev Biol, 2007 Jul 15. PMID 17553483, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables iron ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sulfur dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sulfur dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables sulfur dioxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glutathione metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in hydrogen sulfide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG30022-PB
NP_725047.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    11387160..11388779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165830.3 → NP_725047.2  uncharacterized protein Dmel_CG30022 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725047.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z8L2, Q86PD3
    Conserved Domains (2) summary
    PLN02962
    Location:45 → 277
    PLN02962; hydroxyacylglutathione hydrolase
    cd07724
    Location:49 → 221
    POD-like_MBL-fold; ETHE1 (PDO type I), persulfide dioxygenase A (PDOA, PDO type II) and related proteins; MBL-fold metallo-hydrolase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86PD3 Q86PD3

Gene LinkOut

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