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Cse1l chromosome segregation 1 like [ Rattus norvegicus (Norway rat) ]

Gene ID: 362273, updated on 27-Nov-2024

Summary

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Official Symbol
Cse1lprovided by RGD
Official Full Name
chromosome segregation 1 likeprovided by RGD
Primary source
RGD:1307536
See related
EnsemblRapid:ENSRNOG00000007665 AllianceGenome:RGD:1307536
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable nuclear export signal receptor activity. Predicted to be involved in protein export from nucleus and protein import into nucleus. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nuclear envelope. Orthologous to human CSE1L (chromosome segregation 1 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 195.9), Spleen (RPKM 167.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cse1l in Genome Data Viewer
Location:
3q42
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (176060183..176097909)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (155641104..155678866)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (163664074..163702074)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486207 Neighboring gene ARF guanine nucleotide exchange factor 2 Neighboring gene staufen double-stranded RNA binding protein 1 Neighboring gene uncharacterized LOC108350624

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article
  2. Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry. Moon S, et al. Sci Rep, 2014 Mar 14. PMID 24625528, Free PMC Article
  3. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables nuclear export signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
exportin-2
Names
CSE1 chromosome segregation 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108607.1 → NP_001102077.1  exportin-2

    See identical proteins and their annotated locations for NP_001102077.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474005
    UniProtKB/TrEMBL
    A0A8I5XVR1, A6JXI1, D3ZPR0
    Conserved Domains (3) summary
    smart00913
    Location:29 → 102
    IBN_N; Importin-beta N-terminal domain
    pfam03378
    Location:527 → 962
    CAS_CSE1; CAS/CSE protein, C-terminus
    pfam08506
    Location:156 → 526
    Cse1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    176060183..176097909
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284225.1 → XP_063140295.1  exportin-2 isoform X1

  2. XM_063284227.1 → XP_063140297.1  exportin-2 isoform X1

  3. XM_006235648.5 → XP_006235710.1  exportin-2 isoform X2

    See identical proteins and their annotated locations for XP_006235710.1

    UniProtKB/TrEMBL
    A0A8I5XVR1, A6JXI1, D3ZPR0
    Related
    ENSRNOP00000010210.3, ENSRNOT00000010210.6
    Conserved Domains (3) summary
    smart00913
    Location:29 → 102
    IBN_N; Importin-beta N-terminal domain
    pfam03378
    Location:527 → 962
    CAS_CSE1; CAS/CSE protein, C-terminus
    pfam08506
    Location:156 → 526
    Cse1

  4. XM_063284228.1 → XP_063140298.1  exportin-2 isoform X1

  5. XM_063284229.1 → XP_063140299.1  exportin-2 isoform X2

    UniProtKB/TrEMBL
    A6JXI1, D3ZPR0

  6. XM_063284226.1 → XP_063140296.1  exportin-2 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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