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Snta1 syntrophin, alpha 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362242, updated on 27-Nov-2024

Summary

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Official Symbol
Snta1provided by RGD
Official Full Name
syntrophin, alpha 1provided by RGD
Primary source
RGD:1307068
See related
EnsemblRapid:ENSRNOG00000016062 AllianceGenome:RGD:1307068
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables PDZ domain binding activity. Predicted to be involved in several processes, including negative regulation of peptidyl-cysteine S-nitrosylation; regulation of ventricular cardiac muscle cell membrane repolarization; and ventricular cardiac muscle cell action potential. Predicted to act upstream of or within neuromuscular junction development and regulation of vasoconstriction by circulating norepinephrine. Located in neuromuscular junction and sarcolemma. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in long QT syndrome; long QT syndrome 12; and sudden infant death syndrome. Orthologous to human SNTA1 (syntrophin alpha 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 501.8), Kidney (RPKM 247.9) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Snta1 in Genome Data Viewer
Location:
3q41
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (163336509..163366954, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (142876285..142906737, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (149874023..149905980, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene CDK5 regulatory subunit associated protein 1 Neighboring gene vomeromodulin-like Neighboring gene high mobility group box 1 like 3 Neighboring gene uncharacterized LOC120101761 Neighboring gene CBFA2/RUNX1 partner transcriptional co-repressor 2 Neighboring gene spermine synthase, pseudogene 2 Neighboring gene ribosomal protein S10, pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. beta 2-Syntrophin: localization at the neuromuscular junction in skeletal muscle. Peters MF, et al. Neuroreport, 1994 Aug 15. PMID 7819523
  2. alpha-1-syntrophin mutation and the long-QT syndrome: a disease of sodium channel disruption. Wu G, et al. Circ Arrhythm Electrophysiol, 2008 Aug. PMID 19684871, Free PMC Article
  3. Astroglial loss and edema formation in the rat piriform cortex and hippocampus following pilocarpine-induced status epilepticus. Kim JE, et al. J Comp Neurol, 2010 Nov 15. PMID 20886625
  4. Alpha1-syntrophin mutations identified in sudden infant death syndrome cause an increase in late cardiac sodium current. Cheng J, et al. Circ Arrhythm Electrophysiol, 2009 Dec. PMID 20009079, Free PMC Article
  5. Vasomodulation by skeletal muscle-derived nitric oxide requires alpha-syntrophin-mediated sarcolemmal localization of neuronal Nitric oxide synthase. Thomas GD, et al. Circ Res, 2003 Mar 21. PMID 12600881

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
  
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables nitric-oxide synthase binding ISO
Inferred from Sequence Orthology
more info
  
enables sodium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of peptidyl-cysteine S-nitrosylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuromuscular junction development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of heart rate ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of vasoconstriction by circulating norepinephrine ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ventricular cardiac muscle cell membrane repolarization ISO
Inferred from Sequence Orthology
more info
  
involved_in ventricular cardiac muscle cell action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ventricular cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of dystrophin-associated glycoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuromuscular junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuromuscular junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sarcolemma IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
alpha-1-syntrophin
Names
syntrophin, acidic 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100901.1 → NP_001094371.1  alpha-1-syntrophin

    See identical proteins and their annotated locations for NP_001094371.1

    Status: PROVISIONAL

    Source sequence(s)
    BC169101
    UniProtKB/TrEMBL
    A0A8J8Y1B9, B5DFL0, F1MA17
    Related
    ENSRNOP00000021715.6, ENSRNOT00000021715.8
    Conserved Domains (4) summary
    smart00233
    Location:292 → 395
    PH; Pleckstrin homology domain
    cd00992
    Location:80 → 161
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01258
    Location:206 → 264
    PHsplit_syntrophin; Syntrophin Split Pleckstrin homology (PH) domain
    pfam00169
    Location:292 → 395
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    163336509..163366954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235326.5 → XP_006235388.1  alpha-1-syntrophin isoform X1

    UniProtKB/TrEMBL
    A0A8J8Y1B9
    Conserved Domains (4) summary
    smart00233
    Location:292 → 395
    PH; Pleckstrin homology domain
    cd00992
    Location:80 → 161
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01258
    Location:206 → 264
    PHsplit_syntrophin; Syntrophin Split Pleckstrin homology (PH) domain
    pfam00169
    Location:292 → 395
    PH; PH domain
Nucleotide Protein Strain
Heading Accession and Version

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