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Shf Src homology 2 domain containing F [ Rattus norvegicus (Norway rat) ]

Gene ID: 362205, updated on 4-Jan-2025

Summary

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Symbol
Shfprovided by RGD
Full Name
Src homology 2 domain containing Fprovided by RGD
Primary source
RGD:1562705
See related
EnsemblRapid:ENSRNOG00000028685 AllianceGenome:RGD:1562705
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562705
Summary
Predicted to enable phosphotyrosine residue binding activity. Orthologous to human SHF (Src homology 2 domain containing F). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 132.1), Liver (RPKM 49.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Shf in Genome Data Viewer
Location:
3q35
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (129749903..129769912, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (109296517..109316315, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (114288021..114307334, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene dual oxidase maturation factor 1 Neighboring gene dual oxidase 1 Neighboring gene transfer RNA histidine (anticodon GUG) 7 Neighboring gene transfer RNA histidine (anticodon GUG) 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphotyrosine residue binding IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SH2 domain-containing adapter protein F
Names
formin-like protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430478.1 → NP_001417407.1  SH2 domain-containing adapter protein F isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I5ZUK8, F1M4K0

  2. NM_001430479.1 → NP_001417408.1  SH2 domain-containing adapter protein F isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I5ZUK8

  3. NM_001430480.1 → NP_001417409.1  SH2 domain-containing adapter protein F isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I5ZZG0

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    129749903..129769912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039106536.2 → XP_038962464.1  SH2 domain-containing adapter protein F isoform X4

    Related
    ENSRNOP00000084391.1, ENSRNOT00000102854.2

  2. XM_039106534.2 → XP_038962462.1  SH2 domain-containing adapter protein F isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZUK8
    Conserved Domains (1) summary
    cl15255
    Location:384 → 439
    SH2; Src homology 2 (SH2) domain

  3. XM_039106535.2 → XP_038962463.1  SH2 domain-containing adapter protein F isoform X3

    Related
    ENSRNOP00000082993.1, ENSRNOT00000111933.2
    Conserved Domains (1) summary
    cd10392
    Location:335 → 432
    SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)

  4. XM_008762216.3 → XP_008760438.3  SH2 domain-containing adapter protein F isoform X1

    Related
    ENSRNOP00000059526.4, ENSRNOT00000064592.5
    Conserved Domains (1) summary
    cd10392
    Location:382 → 479
    SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)
Nucleotide Protein Strain
Heading Accession and Version

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