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Arfgap2 ARF GTPase activating protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362162, updated on 27-Nov-2024

Summary

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Official Symbol
Arfgap2provided by RGD
Official Full Name
ARF GTPase activating protein 2provided by RGD
Primary source
RGD:1306177
See related
EnsemblRapid:ENSRNOG00000014429 AllianceGenome:RGD:1306177
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Zfp289
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in COPI coating of Golgi vesicle. Predicted to be located in Golgi apparatus; cytosol; and plasma membrane. Orthologous to human ARFGAP2 (ADP ribosylation factor GTPase activating protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 357.1), Muscle (RPKM 295.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arfgap2 in Genome Data Viewer
Location:
3q24
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (97692105..97704246)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (77236305..77248445)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (80081541..80093659)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene acid phosphatase 2, lysosomal Neighboring gene damage specific DNA binding protein 2 Neighboring gene protein kinase C and casein kinase substrate in neurons 3 Neighboring gene centriolar satellite-associated tubulin polyglutamylase complex regulator 1 Neighboring gene uncharacterized LOC120101910 Neighboring gene U2 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking. Weimer C, et al. J Cell Biol, 2008 Nov 17. PMID 19015319, Free PMC Article
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking
    Title: Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC124884

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in COPI coating of Golgi vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ADP-ribosylation factor GTPase-activating protein 2
Names
ADP-ribosylation factor GTPase activating protein 2
ARF GAP 2
GTPase-activating protein ZNF289
zinc finger protein 289

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033707.1 → NP_001028879.1  ADP-ribosylation factor GTPase-activating protein 2

    See identical proteins and their annotated locations for NP_001028879.1

    Status: PROVISIONAL

    Source sequence(s)
    BC101917
    UniProtKB/Swiss-Prot
    Q3MID3
    UniProtKB/TrEMBL
    A0A8I6A5U9, A6HNC3
    Related
    ENSRNOP00000053988.2, ENSRNOT00000057161.4
    Conserved Domains (2) summary
    PLN03114
    Location:12 → 470
    PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
    cd09029
    Location:5 → 124
    ArfGap_ArfGap2; Arf1 GTPase-activating protein 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    97692105..97704246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234530.5 → XP_006234592.1  ADP-ribosylation factor GTPase-activating protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006234592.1

    UniProtKB/TrEMBL
    A0A8I6A5U9, A6HNC2
    Related
    ENSRNOP00000088256.1, ENSRNOT00000117465.2
    Conserved Domains (2) summary
    PLN03114
    Location:12 → 484
    PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
    smart00105
    Location:14 → 117
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

  2. XM_006234531.5 → XP_006234593.1  ADP-ribosylation factor GTPase-activating protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A5U9
    Conserved Domains (2) summary
    PLN03114
    Location:12 → 479
    PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
    smart00105
    Location:14 → 117
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3MID3.1 GenPept UniProtKB/Swiss-Prot:Q3MID3

Gene LinkOut

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