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Wdsub1 WD repeat, sterile alpha motif and U-box domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362137, updated on 27-Nov-2024

Summary

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Official Symbol
Wdsub1provided by RGD
Official Full Name
WD repeat, sterile alpha motif and U-box domain containing 1provided by RGD
Primary source
RGD:1359296
See related
EnsemblRapid:ENSRNOG00000005990 AllianceGenome:RGD:1359296
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. Orthologous to human WDSUB1 (WD repeat, sterile alpha motif and U-box domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 58.0), Kidney (RPKM 57.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Wdsub1 in Genome Data Viewer
Location:
3q21
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (64749118..64781525, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (44340415..44370890, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (45924979..45955455, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 Neighboring gene uncharacterized LOC134486097 Neighboring gene uncharacterized LOC108350580 Neighboring gene bromodomain adjacent to zinc finger domain, 2B Neighboring gene ADP-ribosylation factor 4, pseudogene 1 Neighboring gene RNA, U6 small nuclear 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC108920

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
WD repeat, SAM and U-box domain-containing protein 1
Names
WD repeat, SAM and U-box domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014179.1 → NP_001014201.1  WD repeat, SAM and U-box domain-containing protein 1

    See identical proteins and their annotated locations for NP_001014201.1

    Status: PROVISIONAL

    Source sequence(s)
    BC089856
    UniProtKB/Swiss-Prot
    Q5FVN8
    UniProtKB/TrEMBL
    A0A8I5Y6I8
    Related
    ENSRNOP00000008168.7, ENSRNOT00000008168.8
    Conserved Domains (4) summary
    cd09505
    Location:328 → 399
    SAM_WDSUB1; SAM domain of WDSUB1 proteins
    cd00200
    Location:4 → 309
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:16 → 52
    7WD40; WD40 repeat [structural motif]
    pfam04564
    Location:404 → 476
    U-box; U-box domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    64749118..64781525 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284111.1 → XP_063140181.1  WD repeat, SAM and U-box domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A0H2UHE3

  2. XM_006234211.5 → XP_006234273.1  WD repeat, SAM and U-box domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006234273.1

    UniProtKB/Swiss-Prot
    Q5FVN8
    UniProtKB/TrEMBL
    A0A8I5Y6I8
    Conserved Domains (4) summary
    cd09505
    Location:328 → 399
    SAM_WDSUB1; SAM domain of WDSUB1 proteins
    cd00200
    Location:4 → 309
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:16 → 52
    7WD40; WD40 repeat [structural motif]
    pfam04564
    Location:404 → 476
    U-box; U-box domain

  3. XM_017591892.2 → XP_017447381.1  WD repeat, SAM and U-box domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A0H2UHE3, A0A8I5Y6I8

  4. XM_039105392.2 → XP_038961320.1  WD repeat, SAM and U-box domain-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    A6JF69
    Conserved Domains (2) summary
    cd00200
    Location:4 → 258
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:16 → 52
    7WD40; WD40 repeat [structural motif]

  5. XM_063284112.1 → XP_063140182.1  WD repeat, SAM and U-box domain-containing protein 1 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FVN8.1 GenPept UniProtKB/Swiss-Prot:Q5FVN8

Gene LinkOut

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