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Gtdc1 glycosyltransferase-like domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362129, updated on 4-Jan-2025

Summary

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Official Symbol
Gtdc1provided by RGD
Official Full Name
glycosyltransferase-like domain containing 1provided by RGD
Primary source
RGD:1563393
See related
EnsemblRapid:ENSRNOG00000031038 AllianceGenome:RGD:1563393
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
QTMAN
Summary
Enables tRNA-queuosine(34) beta-mannosyltransferase activity. Involved in tRNA modification. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human GTDC1 (glycosyltransferase like domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 84.1), Lung (RPKM 55.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gtdc1 in Genome Data Viewer
Location:
3q12
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (49176110..49571594, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (28766640..29161668, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (29410426..29705981, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 15 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC134486356 Neighboring gene uncharacterized LOC134486357 Neighboring gene uncharacterized LOC108350367 Neighboring gene RNA, U2 small nuclear 18 Neighboring gene zinc finger E-box binding homeobox 2 Neighboring gene ZEB2 antisense RNA 1 Neighboring gene uncharacterized LOC102548671

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth. Zhao X, et al. Cell, 2023 Dec 7. PMID 37992713

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-queuosine(34) beta-mannosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA-queuosine(34) beta-mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-queuosine(34) beta-mannosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA modification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA modification IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA modification ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tRNA-queuosine alpha-mannosyltransferase; glycosyltransferase-like domain-containing protein 1
Names
glycosyltransferase-like protein
NP_001019445.1
NP_001380618.1
XP_063140150.1
XP_063140151.1
XP_063140152.1
XP_063140153.1
XP_063140154.1
XP_063140155.1
XP_063140156.1
XP_063140157.1
XP_063140158.1
XP_063140159.1
XP_063140160.1
XP_063140161.1
XP_063140162.1
XP_063140163.1
XP_063140164.1
XP_063140165.1
XP_063140166.1
XP_063140167.1
XP_063140168.1
XP_063140169.1
XP_063140170.1
XP_063140171.1
XP_063140172.1
XP_063140173.1
XP_063140174.1
XP_063140175.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024274.2 → NP_001019445.1  tRNA-queuosine alpha-mannosyltransferase isoform 2

    See identical proteins and their annotated locations for NP_001019445.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q53E76
    UniProtKB/TrEMBL
    A0A8I5ZP27
    Related
    ENSRNOP00000056430.1, ENSRNOT00000059679.3
    Conserved Domains (3) summary
    COG0438
    Location:222 → 381
    RfaB; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    pfam12038
    Location:2 → 108
    DUF3524; Domain of unknown function (DUF3524)
    cl10013
    Location:221 → 389
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

  2. NM_001393689.1 → NP_001380618.1  tRNA-queuosine alpha-mannosyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I5ZP27, A0A8I6GA65, A6JEX6
    Related
    ENSRNOP00000082987.1, ENSRNOT00000109271.2
    Conserved Domains (2) summary
    cd01635
    Location:275 → 386
    Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology
    pfam12038
    Location:2 → 164
    DUF3524; Domain of unknown function (DUF3524)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    49176110..49571594 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284086.1 → XP_063140156.1  glycosyltransferase-like domain-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZP27, A0A8I6A338
    Related
    ENSRNOP00000110521.1, ENSRNOT00000142395.1

  2. XM_063284099.1 → XP_063140169.1  glycosyltransferase-like domain-containing protein 1 isoform X13

  3. XM_063284085.1 → XP_063140155.1  glycosyltransferase-like domain-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZP27, A0A8I6A338

  4. XM_063284098.1 → XP_063140168.1  glycosyltransferase-like domain-containing protein 1 isoform X13

  5. XM_063284102.1 → XP_063140172.1  glycosyltransferase-like domain-containing protein 1 isoform X13

  6. XM_063284083.1 → XP_063140153.1  glycosyltransferase-like domain-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZP27, A0A8I6A338

  7. XM_063284090.1 → XP_063140160.1  glycosyltransferase-like domain-containing protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZP27, A0A8I6GA65, A6JEX6

  8. XM_063284084.1 → XP_063140154.1  glycosyltransferase-like domain-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZP27, A0A8I6A338

  9. XM_063284087.1 → XP_063140157.1  glycosyltransferase-like domain-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZP27, A0A8I6A338
    Related
    ENSRNOP00000079984.2, ENSRNOT00000108792.2

  10. XM_063284091.1 → XP_063140161.1  glycosyltransferase-like domain-containing protein 1 isoform X6

  11. XM_063284080.1 → XP_063140150.1  glycosyltransferase-like domain-containing protein 1 isoform X1

  12. XM_063284092.1 → XP_063140162.1  glycosyltransferase-like domain-containing protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZP27

  13. XM_063284081.1 → XP_063140151.1  glycosyltransferase-like domain-containing protein 1 isoform X2

    Related
    ENSRNOP00000112599.1, ENSRNOT00000143060.1

  14. XM_063284089.1 → XP_063140159.1  glycosyltransferase-like domain-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZP27, A0A8I6A338
    Related
    ENSRNOP00000103343.1, ENSRNOT00000171954.1

  15. XM_063284088.1 → XP_063140158.1  glycosyltransferase-like domain-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZP27, A0A8I6A338

  16. XM_063284101.1 → XP_063140171.1  glycosyltransferase-like domain-containing protein 1 isoform X14

  17. XM_063284100.1 → XP_063140170.1  glycosyltransferase-like domain-containing protein 1 isoform X14

  18. XM_063284095.1 → XP_063140165.1  glycosyltransferase-like domain-containing protein 1 isoform X10

    UniProtKB/TrEMBL
    A0A8I5ZP27

  19. XM_063284096.1 → XP_063140166.1  glycosyltransferase-like domain-containing protein 1 isoform X11

  20. XM_063284082.1 → XP_063140152.1  glycosyltransferase-like domain-containing protein 1 isoform X3

  21. XM_063284093.1 → XP_063140163.1  glycosyltransferase-like domain-containing protein 1 isoform X8

  22. XM_063284097.1 → XP_063140167.1  glycosyltransferase-like domain-containing protein 1 isoform X12

    UniProtKB/TrEMBL
    A6JEX7

  23. XM_063284094.1 → XP_063140164.1  glycosyltransferase-like domain-containing protein 1 isoform X9

  24. XM_063284104.1 → XP_063140174.1  glycosyltransferase-like domain-containing protein 1 isoform X16

  25. XM_063284105.1 → XP_063140175.1  glycosyltransferase-like domain-containing protein 1 isoform X17

  26. XM_063284103.1 → XP_063140173.1  glycosyltransferase-like domain-containing protein 1 isoform X15

RNA

  1. XR_010064658.1 RNA Sequence

  2. XR_010064659.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q53E76.1 GenPept UniProtKB/Swiss-Prot:Q53E76

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