Kpna4 karyopherin subunit alpha 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kpna4provided by RGD
Official Full Name: karyopherin subunit alpha 4provided by RGD
Primary source: RGD:1311483
See related: EnsemblRapid:ENSRNOG00000010768 AllianceGenome:RGD:1311483
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: importin
Summary: Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to act upstream of with a positive effect on dopamine secretion and gene expression. Predicted to act upstream of or within protein import into nucleus and response to hydrogen peroxide. Predicted to be located in male germ cell nucleus and nuclear membrane. Predicted to be part of NLS-dependent protein nuclear import complex and nuclear pore. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human KPNA4 (karyopherin subunit alpha 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Muscle (RPKM 566.5), Heart (RPKM 427.2) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 2q32

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (155635679..155691056, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (153319380..153381085, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (165684345..165739874, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A detailed analysis to characterize the molecular components underlying the nuclear translocation of TP2, was carried out.
Title: Involvement of importin-4 in the transport of transition protein 2 into the spermatid nucleus.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

WIAF-1631 (e-PCR)
- UniSTS:19006

GDB:451532 (e-PCR)
- UniSTS:157306

Kpna4 (e-PCR), detects polymorphism
- UniSTS:507011

AA924555 (e-PCR)
- UniSTS:248215

HSC0TF112 (e-PCR)
- UniSTS:76455

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear import signal receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear localization sequence binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in NLS-bearing protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in NLS-bearing protein import into nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect dopamine secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of NLS-dependent protein nuclear import complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in male germ cell nucleus	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: importin subunit alpha-3

Names: importin subunit alpha-4; karyopherin (importin) alpha 4; karyopherin alpha 4 (importin alpha 3); predicted role in nuclear import

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014793.1 → NP_001014793.1 importin subunit alpha-3

See identical proteins and their annotated locations for NP_001014793.1

Status: PROVISIONAL

Source sequence(s)

AY779028

UniProtKB/TrEMBL

F7FQB8, Q56R17

Related

ENSRNOP00000100890.1, ENSRNOT00000123454.1

Conserved Domains (2) summary

COG5064
Location:11 → 513

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:279 → 311

ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

155635679..155691056 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102632.2 → XP_038958560.1 importin subunit alpha-3 isoform X1

Related

ENSRNOP00000109492.1, ENSRNOT00000163005.1

Conserved Domains (2) summary

COG5064
Location:11 → 459

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:279 → 311

ARM; armadillo repeat [structural motif]