Hace1 HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hace1provided by RGD
Official Full Name: HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1provided by RGD
Primary source: RGD:1306114
See related: EnsemblRapid:ENSRNOG00000000327 AllianceGenome:RGD:1306114
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable small GTPase binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including Golgi organization; protein K48-linked ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in endoplasmic reticulum and nuclear body. Predicted to be active in Golgi membrane and nucleus. Orthologous to human HACE1 (HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 149.9), Lung (RPKM 78.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q13

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (50618004..50733460)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (49035312..49151103)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (50652489..50783937)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression analysis of the human Hace1 ortholog and demonstration of its ubiquitin ligase activity.
Title: Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in Golgi organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane fusion	ISO Inferred from Sequence Orthology more info
involved_in membrane fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase HACE1

Names: HECT-type E3 ubiquitin transferase HACE1

NP_001102009.2

EC 2.3.2.26

XP_006256657.1

EC 2.3.2.26

XP_006256659.1

EC 2.3.2.26

XP_038954817.1

EC 2.3.2.26

XP_038954818.1

EC 2.3.2.26

XP_038954819.1

EC 2.3.2.26

XP_038954820.1

EC 2.3.2.26

XP_038954822.1

EC 2.3.2.26

XP_038954823.1

EC 2.3.2.26

XP_038954824.1

EC 2.3.2.26

XP_038954825.1

EC 2.3.2.26

XP_038954826.1

EC 2.3.2.26

XP_038954827.1

EC 2.3.2.26

XP_063135390.1

EC 2.3.2.26

XP_063135391.1

EC 2.3.2.26

XP_063135392.1

EC 2.3.2.26

XP_063135394.1

EC 2.3.2.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108539.3 → NP_001102009.2 E3 ubiquitin-protein ligase HACE1

See identical proteins and their annotated locations for NP_001102009.2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

D3ZBM7, D3ZBM8

UniProtKB/TrEMBL

A0A8I6ADJ5

Related

ENSRNOP00000000365.4, ENSRNOT00000000365.6

Conserved Domains (7) summary

smart00248
Location:66 → 93

ANK; ankyrin repeats

smart00119
Location:579 → 902

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:554 → 903

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00204
Location:92 → 217

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:69 → 194

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:199 → 249

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:97 → 128

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

50618004..50733460

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006256595.5 → XP_006256657.1 E3 ubiquitin-protein ligase HACE1 isoform X1

UniProtKB/TrEMBL

A0A8I6ADJ5

Related

ENSRNOP00000090381.1, ENSRNOT00000111799.2

Conserved Domains (7) summary

smart00248
Location:66 → 93

ANK; ankyrin repeats

smart00119
Location:586 → 909

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:561 → 910

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00204
Location:92 → 217

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:69 → 194

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:199 → 249

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:97 → 128

ANK; ANK repeat [structural motif]
XM_006256597.5 → XP_006256659.1 E3 ubiquitin-protein ligase HACE1 isoform X7

UniProtKB/TrEMBL

A0A8I6ADJ5

Related

ENSRNOP00000104608.1, ENSRNOT00000139890.1

Conserved Domains (7) summary

smart00248
Location:66 → 93

ANK; ankyrin repeats

smart00119
Location:586 → 865

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:561 → 866

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00204
Location:92 → 217

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:69 → 194

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:199 → 249

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:97 → 128

ANK; ANK repeat [structural motif]
XM_039098889.2 → XP_038954817.1 E3 ubiquitin-protein ligase HACE1 isoform X2

UniProtKB/TrEMBL

A0A8I6ADJ5

Conserved Domains (4) summary

COG0666
Location:83 → 220

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00078
Location:561 → 893

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

sd00045
Location:97 → 128

ANK; ANK repeat [structural motif]

pfam12796
Location:34 → 126

Ank_2; Ankyrin repeats (3 copies)
XM_063279320.1 → XP_063135390.1 E3 ubiquitin-protein ligase HACE1 isoform X3
XM_039098892.2 → XP_038954820.1 E3 ubiquitin-protein ligase HACE1 isoform X8

UniProtKB/TrEMBL

A0A8I6A1L8

Conserved Domains (4) summary

cd00078
Location:517 → 866

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

sd00045
Location:66 → 95

ANK; ANK repeat [structural motif]

pfam12796
Location:69 → 179

Ank_2; Ankyrin repeats (3 copies)

cl39094
Location:157 → 207

Ank_2; Ankyrin repeats (3 copies)
XM_039098894.2 → XP_038954822.1 E3 ubiquitin-protein ligase HACE1 isoform X9

UniProtKB/TrEMBL

A0A8I6A1L8

Related

ENSRNOP00000107784.1, ENSRNOT00000141456.1

Conserved Domains (4) summary

cd00078
Location:510 → 859

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

sd00045
Location:66 → 95

ANK; ANK repeat [structural motif]

pfam12796
Location:69 → 179

Ank_2; Ankyrin repeats (3 copies)

cl39094
Location:157 → 207

Ank_2; Ankyrin repeats (3 copies)
XM_039098891.2 → XP_038954819.1 E3 ubiquitin-protein ligase HACE1 isoform X5

UniProtKB/TrEMBL

A0A8I6A1L8

Related

ENSRNOP00000101439.1, ENSRNOT00000146450.1

Conserved Domains (3) summary

COG0666
Location:33 → 185

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00078
Location:526 → 875

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

sd00045
Location:95 → 126

ANK; ANK repeat [structural motif]
XM_039098895.2 → XP_038954823.1 E3 ubiquitin-protein ligase HACE1 isoform X11

UniProtKB/TrEMBL

A0A8I6A1L8

Conserved Domains (3) summary

cd00078
Location:482 → 831

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

sd00045
Location:66 → 115

ANK; ANK repeat [structural motif]

pfam12796
Location:69 → 172

Ank_2; Ankyrin repeats (3 copies)
XM_039098890.2 → XP_038954818.1 E3 ubiquitin-protein ligase HACE1 isoform X4

UniProtKB/TrEMBL

A0A8I6A1L8

Conserved Domains (3) summary

COG0666
Location:53 → 190

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00078
Location:531 → 880

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

sd00045
Location:67 → 98

ANK; ANK repeat [structural motif]
XM_063279321.1 → XP_063135391.1 E3 ubiquitin-protein ligase HACE1 isoform X6

Related

ENSRNOP00000085147.2, ENSRNOT00000106005.2
XM_063279322.1 → XP_063135392.1 E3 ubiquitin-protein ligase HACE1 isoform X10

Related

ENSRNOP00000110872.1, ENSRNOT00000130620.1
XM_039098899.2 → XP_038954827.1 E3 ubiquitin-protein ligase HACE1 isoform X15

UniProtKB/TrEMBL

A6K6U6

Conserved Domains (3) summary

COG0666
Location:83 → 220

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:97 → 128

ANK; ANK repeat [structural motif]

pfam12796
Location:34 → 126

Ank_2; Ankyrin repeats (3 copies)
XM_039098896.2 → XP_038954824.1 E3 ubiquitin-protein ligase HACE1 isoform X12

UniProtKB/TrEMBL

A0A8I6A1L8

Conserved Domains (4) summary

cd00078
Location:448 → 797

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

sd00045
Location:17 → 48

ANK; ANK repeat [structural motif]

pfam13637
Location:4 → 38

Ank_4; Ankyrin repeats (many copies)

pfam12796
Location:22 → 110

Ank_2; Ankyrin repeats (3 copies)
XM_063279324.1 → XP_063135394.1 E3 ubiquitin-protein ligase HACE1 isoform X12
XM_039098897.2 → XP_038954825.1 E3 ubiquitin-protein ligase HACE1 isoform X13

UniProtKB/TrEMBL

A0A8I6A1L8

Conserved Domains (1) summary

cd00078
Location:393 → 742

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
XM_039098898.2 → XP_038954826.1 E3 ubiquitin-protein ligase HACE1 isoform X14

UniProtKB/TrEMBL

A0A8I6A1L8

Conserved Domains (1) summary

cd00078
Location:386 → 735

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...