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Slc25a16 solute carrier family 25 member 16 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361836, updated on 4-Jan-2025

Summary

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Official Symbol
Slc25a16provided by RGD
Official Full Name
solute carrier family 25 member 16provided by RGD
Primary source
RGD:1311311
See related
EnsemblRapid:ENSRNOG00000000387 EnsemblRapid:ENSRNOG00000071263 AllianceGenome:RGD:1311311
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable coenzyme A transmembrane transporter activity. Predicted to be involved in mitochondrial coenzyme A transmembrane transport. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Orthologous to human SLC25A16 (solute carrier family 25 member 16). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 96.2), Kidney (RPKM 96.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc25a16 in Genome Data Viewer
Location:
20q11
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (25659847..25717080, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (25691474..25717558, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (27283383..27308069, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene phenazine biosynthesis-like protein domain containing 2 Neighboring gene RUN and FYVE domain containing 2 Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein H3 Neighboring gene DNA replication helicase/nuclease 2 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene U6 spliceosomal RNA Neighboring gene elongin C, pseduogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Sequence and chromosomal assignment of a novel cDNA identified by immunoscreening of a thyroid expression library: similarity to a family of mitochondrial solute carrier proteins. Zarrilli R, et al. Mol Endocrinol, 1989 Sep. PMID 2575220
  2. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 5'-flap endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables coenzyme A transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication, Okazaki fragment processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial coenzyme A transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 25 member 16
Names
GDC
graves disease carrier protein
mitochondrial solute carrier protein homolog
solute carrier family 25 (mitochondrial carrier), member 16
solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100860.4 → NP_001094330.1  solute carrier family 25 member 16 isoform 1

    See identical proteins and their annotated locations for NP_001094330.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/Swiss-Prot
    P16261
    UniProtKB/TrEMBL
    A0A9K3Y7D2, B2GV20, F1MA22
    Related
    ENSRNOP00000052899.5, ENSRNOT00000056047.5
    Conserved Domains (1) summary
    PTZ00169
    Location:36 → 330
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

  2. NM_001429292.1 → NP_001416221.1  solute carrier family 25 member 16 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/TrEMBL
    A6JL05

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    25659847..25717080 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279286.1 → XP_063135356.1  solute carrier family 25 member 16 isoform X1

    UniProtKB/Swiss-Prot
    D3ZG52
    UniProtKB/TrEMBL
    A0A8I5ZZI9
    Related
    ENSRNOP00000083522.1, ENSRNOT00000103093.3

  2. XM_063279289.1 → XP_063135359.1  solute carrier family 25 member 16 isoform X4

  3. XM_063279288.1 → XP_063135358.1  solute carrier family 25 member 16 isoform X3

  4. XM_063279287.1 → XP_063135357.1  solute carrier family 25 member 16 isoform X2

    UniProtKB/Swiss-Prot
    D3ZG52

  5. XM_039098864.2 → XP_038954792.1  solute carrier family 25 member 16 isoform X5

    UniProtKB/Swiss-Prot
    P16261
    Conserved Domains (1) summary
    PTZ00169
    Location:36 → 272
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16261.1 GenPept UniProtKB/Swiss-Prot:P16261

Gene LinkOut

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