U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Srpk1 SRSF protein kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361811, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Srpk1provided by RGD
Official Full Name
SRSF protein kinase 1provided by RGD
Primary source
RGD:1308272
See related
EnsemblRapid:ENSRNOG00000000511 AllianceGenome:RGD:1308272
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including regulation of mRNA processing; regulation of viral genome replication; and spliceosomal complex assembly. Predicted to be located in several cellular components, including chromatin; cytosol; and nuclear speck. Predicted to be active in cytoplasm and nucleus. Orthologous to human SRPK1 (SRSF protein kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 179.0), Thymus (RPKM 144.8) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Srpk1 in Genome Data Viewer
Location:
20p12
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (6647539..6684129, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (6645809..6682448, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5829412..5865877, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene colipase Neighboring gene LHFPL tetraspan subfamily member 5 Neighboring gene uncharacterized LOC120098971 Neighboring gene solute carrier family 26 member 8 Neighboring gene mitogen activated protein kinase 14

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Downregulation of long noncoding RNA DLEU1 attenuates hypersensitivity in chronic constriction injury-induced neuropathic pain in rats by targeting miR-133a-3p/SRPK1 axis. Li Z, et al. Mol Med, 2020 Nov 10. PMID 33167866, Free PMC Article
  2. SRPK1 gene silencing promotes vascular smooth muscle cell proliferation and vascular remodeling via inhibition of the PI3K/Akt signaling pathway in a rat model of intracranial aneurysms. Li XG, et al. CNS Neurosci Ther, 2019 Feb. PMID 30101479, Free PMC Article
  3. Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase. Karakama Y, et al. Antimicrob Agents Chemother, 2010 Aug. PMID 20498328, Free PMC Article
  4. Cloning and characterization of an alternatively spliced form of SR protein kinase 1 that interacts specifically with scaffold attachment factor-B. Nikolakaki E, et al. J Biol Chem, 2001 Oct 26. PMID 11509566
  5. Human autoimmune sera as molecular probes for the identification of an autoantigen kinase signaling pathway. Kamachi M, et al. J Exp Med, 2002 Nov 4. PMID 12417631, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of long noncoding RNA DLEU1 attenuates hypersensitivity in chronic constriction injury-induced neuropathic pain in rats by targeting miR-133a-3p/SRPK1 axis.
    Title: Downregulation of long noncoding RNA DLEU1 attenuates hypersensitivity in chronic constriction injury-induced neuropathic pain in rats by targeting miR-133a-3p/SRPK1 axis.
  2. The vascular walls in Intracranial aneurysm rat models produced high levels of SRPK1 expression and an activated PI3 K/Akt signaling pathway
    Title: SRPK1 gene silencing promotes vascular smooth muscle cell proliferation and vascular remodeling via inhibition of the PI3K/Akt signaling pathway in a rat model of intracranial aneurysms.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC116186

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in spliceosomal complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
SRSF protein kinase 1
Names
SFRS protein kinase 1
serine/arginine-rich protein specific kinase 1
serine/threonine-protein kinase SRPK1
NP_001020897.1
XP_038954749.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025726.1 → NP_001020897.1  SRSF protein kinase 1

    See identical proteins and their annotated locations for NP_001020897.1

    Status: PROVISIONAL

    Source sequence(s)
    BC099089
    UniProtKB/TrEMBL
    A0A0U1RRU0, A0A9K3Y6Q8, E9PTN4, Q4KLN3
    Related
    ENSRNOP00000000612.8, ENSRNOT00000000612.9
    Conserved Domains (2) summary
    smart00220
    Location:80 → 224
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:70 → 653
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    6647539..6684129 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098821.2 → XP_038954749.1  SRSF protein kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A0U1RRU0
    Conserved Domains (1) summary
    cl21453
    Location:1 → 546
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools