Btrc beta-transducin repeat containing E3 ubiquitin protein ligase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Btrcprovided by RGD
Official Full Name: beta-transducin repeat containing E3 ubiquitin protein ligaseprovided by RGD
Primary source: RGD:1359721
See related: EnsemblRapid:ENSRNOG00000016280 AllianceGenome:RGD:1359721
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: beta-TrCP1
Summary: Predicted to enable several functions, including beta-catenin binding activity; ubiquitin ligase activator activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including positive regulation of macromolecule metabolic process; protein destabilization; and regulation of signal transduction. Predicted to act upstream of or within several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; mammary gland epithelium development; and protein K48-linked ubiquitination. Predicted to be located in cytoplasm and nucleus. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human BTRC (beta-transducin repeat containing E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 58.5), Adrenal (RPKM 48.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (254159085..254324819)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (244210299..244380126)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (265100094..265270263)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of betaTRCP1 increases the polyubiquitylation of EEF2K in PC12 cells.
Title: Proteasomal degradation of eukaryotic elongation factor-2 kinase (EF2K) is regulated by cAMP-PKA signaling and the SCFβTRCP ubiquitin E3 ligase.
postsynaptic RapGAP SPAR is regulated by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neurons.
Title: Regulation of postsynaptic RapGAP SPAR by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neurons.
Crosstalk between the Wnt cascade and NF-kappaB signaling in vascular smooth muscle cells is mediated through the E3-ligase, beta-TrCP1, which increases IkappaBalpha degradation.
Title: The role of [beta]-transducin repeat-containing protein ([beta]-TrCP) in the regulation of NF-[kappa]B in vascular smooth muscle cells.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH138908 (e-PCR)
- UniSTS:220995

Btrc (e-PCR), detects polymorphism
- UniSTS:545904

Btrc (e-PCR), detects polymorphism
- UniSTS:506756

D1Got234 (e-PCR)
- UniSTS:114340

BF412449 (e-PCR)
- UniSTS:248235

AU025303 (e-PCR)
- UniSTS:115395

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein phosphorylated amino acid binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin ligase activator activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mammary gland epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: F-box/WD repeat-containing protein 1A

Names: beta-transducin repeat containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007148.2 → NP_001007149.2 F-box/WD repeat-containing protein 1A

Status: VALIDATED

Source sequence(s)

BC085125, CB584165, EV771066

UniProtKB/TrEMBL

A0A8I5ZMD6, A0A8I6G2R1

Conserved Domains (5) summary

COG2319
Location:304 → 602

WD40; WD40 repeat [General function prediction only]

cd00200
Location:317 → 595

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam12125
Location:153 → 191

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:195 → 242

F-box-like; F-box-like

sd00039
Location:320 → 355

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

254159085..254324819

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006231530.5 → XP_006231592.1 F-box/WD repeat-containing protein 1A isoform X1

UniProtKB/TrEMBL

A0A8I5ZMD6, F1LMH8

Related

ENSRNOP00000082092.2, ENSRNOT00000105576.2

Conserved Domains (5) summary

COG2319
Location:290 → 588

WD40; WD40 repeat [General function prediction only]

cd00200
Location:303 → 581

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam12125
Location:139 → 177

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:181 → 228

F-box-like; F-box-like

sd00039
Location:306 → 341

7WD40; WD40 repeat [structural motif]
XM_006231538.5 → XP_006231600.1 F-box/WD repeat-containing protein 1A isoform X7

See identical proteins and their annotated locations for XP_006231600.1

UniProtKB/TrEMBL

A0A8I5ZMD6, A0A8I6GHM9, A6JHI3

Related

ENSRNOP00000093279.2, ENSRNOT00000105391.2

Conserved Domains (5) summary

COG2319
Location:254 → 552

WD40; WD40 repeat [General function prediction only]

cd00200
Location:267 → 545

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam12125
Location:103 → 141

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:145 → 192

F-box-like; F-box-like

sd00039
Location:270 → 305

7WD40; WD40 repeat [structural motif]
XM_006231536.5 → XP_006231598.1 F-box/WD repeat-containing protein 1A isoform X4

UniProtKB/TrEMBL

A0A8I5ZMD6, A0A8I6AFI6

Related

ENSRNOP00000091578.2, ENSRNOT00000105194.2

Conserved Domains (5) summary

COG2319
Location:268 → 566

WD40; WD40 repeat [General function prediction only]

cd00200
Location:281 → 559

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam12125
Location:117 → 155

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:159 → 206

F-box-like; F-box-like

sd00039
Location:284 → 319

7WD40; WD40 repeat [structural motif]
XM_006231531.5 → XP_006231593.1 F-box/WD repeat-containing protein 1A isoform X2

UniProtKB/TrEMBL

A0A8I5ZMD6, A0A8I5ZRU0

Conserved Domains (5) summary

COG2319
Location:278 → 576

WD40; WD40 repeat [General function prediction only]

cd00200
Location:291 → 569

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam12125
Location:127 → 165

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:169 → 216

F-box-like; F-box-like

sd00039
Location:294 → 329

7WD40; WD40 repeat [structural motif]
XM_039084629.2 → XP_038940557.1 F-box/WD repeat-containing protein 1A isoform X9

UniProtKB/TrEMBL

A0A8I5ZMD6

Related

ENSRNOP00000083705.2, ENSRNOT00000117570.2

Conserved Domains (4) summary

cd00200
Location:255 → 533

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:258 → 293

7WD40; WD40 repeat [structural motif]

pfam12125
Location:91 → 129

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:133 → 180

F-box-like
XM_039084604.2 → XP_038940532.1 F-box/WD repeat-containing protein 1A isoform X5

UniProtKB/TrEMBL

A0A8I5ZMD6

Related

ENSRNOP00000081511.2, ENSRNOT00000105215.2

Conserved Domains (4) summary

cd00200
Location:277 → 555

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:280 → 315

7WD40; WD40 repeat [structural motif]

pfam12125
Location:113 → 151

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:155 → 202

F-box-like
XM_039084634.2 → XP_038940562.1 F-box/WD repeat-containing protein 1A isoform X10

UniProtKB/TrEMBL

A0A8I5ZMD6

Related

ENSRNOP00000089782.2, ENSRNOT00000093843.2

Conserved Domains (4) summary

cd00200
Location:241 → 519

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:244 → 279

7WD40; WD40 repeat [structural motif]

pfam12125
Location:77 → 115

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:119 → 166

F-box-like
XM_039084642.2 → XP_038940570.1 F-box/WD repeat-containing protein 1A isoform X11

UniProtKB/TrEMBL

A0A8I5ZWB9, Q5U4E5

Conserved Domains (4) summary

cd00200
Location:204 → 482

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:207 → 242

7WD40; WD40 repeat [structural motif]

pfam12125
Location:40 → 78

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:82 → 129

F-box-like
XM_063268695.1 → XP_063124765.1 F-box/WD repeat-containing protein 1A isoform X3

UniProtKB/TrEMBL

A0A8I5ZX54

Related

ENSRNOP00000078424.2, ENSRNOT00000118041.2
XM_063268700.1 → XP_063124770.1 F-box/WD repeat-containing protein 1A isoform X3

UniProtKB/TrEMBL

A0A8I5ZX54
XM_063268728.1 → XP_063124798.1 F-box/WD repeat-containing protein 1A isoform X8
XM_063268703.1 → XP_063124773.1 F-box/WD repeat-containing protein 1A isoform X3

UniProtKB/TrEMBL

A0A8I5ZX54
XM_063268710.1 → XP_063124780.1 F-box/WD repeat-containing protein 1A isoform X3

UniProtKB/TrEMBL

A0A8I5ZX54
XM_063268731.1 → XP_063124801.1 F-box/WD repeat-containing protein 1A isoform X8
XM_039084638.2 → XP_038940566.1 F-box/WD repeat-containing protein 1A isoform X11

UniProtKB/TrEMBL

A0A8I5ZWB9, Q5U4E5

Conserved Domains (4) summary

cd00200
Location:204 → 482

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:207 → 242

7WD40; WD40 repeat [structural motif]

pfam12125
Location:40 → 78

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:82 → 129

F-box-like
XM_039084594.2 → XP_038940522.1 F-box/WD repeat-containing protein 1A isoform X3

UniProtKB/TrEMBL

A0A8I5ZMD6, A0A8I5ZX54

Conserved Domains (4) summary

cd00200
Location:285 → 563

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:288 → 323

7WD40; WD40 repeat [structural motif]

pfam12125
Location:121 → 159

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:163 → 210

F-box-like
XM_063268730.1 → XP_063124800.1 F-box/WD repeat-containing protein 1A isoform X8
XM_063268715.1 → XP_063124785.1 F-box/WD repeat-containing protein 1A isoform X6

UniProtKB/TrEMBL

A0A8I6ASK3
XM_017589455.3 → XP_017444944.1 F-box/WD repeat-containing protein 1A isoform X3

UniProtKB/TrEMBL

A0A8I5ZMD6, A0A8I5ZX54

Related

ENSRNOP00000022426.7, ENSRNOT00000022426.9

Conserved Domains (4) summary

cd00200
Location:285 → 563

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:288 → 323

7WD40; WD40 repeat [structural motif]

pfam12125
Location:121 → 159

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:163 → 210

F-box-like
XM_039084622.2 → XP_038940550.1 F-box/WD repeat-containing protein 1A isoform X8

UniProtKB/TrEMBL

A0A8I5ZMD6

Conserved Domains (4) summary

cd00200
Location:259 → 537

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:262 → 297

7WD40; WD40 repeat [structural motif]

pfam12125
Location:95 → 133

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:137 → 184

F-box-like
XM_006231539.5 → XP_006231601.1 F-box/WD repeat-containing protein 1A isoform X11

See identical proteins and their annotated locations for XP_006231601.1

UniProtKB/TrEMBL

A0A8I5ZWB9, Q5U4E5

Conserved Domains (4) summary

cd00200
Location:204 → 482

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:207 → 242

7WD40; WD40 repeat [structural motif]

pfam12125
Location:40 → 78

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:82 → 129

F-box-like