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Cutc cutC copper transporter [ Rattus norvegicus (Norway rat) ]

Gene ID: 361760, updated on 27-Nov-2024

Summary

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Official Symbol
Cutcprovided by RGD
Official Full Name
cutC copper transporterprovided by RGD
Primary source
RGD:1304966
See related
EnsemblRapid:ENSRNOG00000017298 AllianceGenome:RGD:1304966
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable copper ion binding activity. Predicted to be involved in protein tetramerization. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Orthologous to human CUTC (cutC copper transporter). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 96.5), Thymus (RPKM 89.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cutc in Genome Data Viewer
Location:
1q54
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (252571489..252586269)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (242622281..242637048)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (263511537..263526308)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ectonucleoside triphosphate diphosphohydrolase 7 Neighboring gene cytochrome c oxidase assembly homolog COX15 Neighboring gene cystatin B, pseudogene 1 Neighboring gene ATP binding cassette subfamily C member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterization of a novel Cut family cDNA that encodes human copper transporter protein CutC. Li J, et al. Biochem Biophys Res Commun, 2005 Nov 11. PMID 16182249
  2. Crystal structure of human copper homeostasis protein CutC reveals a potential copper-binding site. Li Y, et al. J Struct Biol, 2010 Mar. PMID 19878721
  3. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables copper ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables copper ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein tetramerization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
copper homeostasis protein cutC homolog
Names
cutC copper transporter homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108525.2 → NP_001101995.1  copper homeostasis protein cutC homolog isoform 2

    See identical proteins and their annotated locations for NP_001101995.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I5ZQP8, A6JHD8, D4A6T5
    Related
    ENSRNOP00000087550.1, ENSRNOT00000113769.2
    Conserved Domains (1) summary
    COG3142
    Location:26 → 262
    CutC; Copper homeostasis protein CutC [Inorganic ion transport and metabolism]

  2. NM_001399691.1 → NP_001386620.1  copper homeostasis protein cutC homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    Related
    ENSRNOP00000023396.7, ENSRNOT00000023396.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    252571489..252586269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039084563.2 → XP_038940491.1  copper homeostasis protein cutC homolog isoform X4

    Conserved Domains (1) summary
    cl29988
    Location:26 → 184
    CutC; CutC family

  2. XM_063268682.1 → XP_063124752.1  copper homeostasis protein cutC homolog isoform X3

  3. XM_006231527.3 → XP_006231589.1  copper homeostasis protein cutC homolog isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZQP8
    Related
    ENSRNOP00000080809.1, ENSRNOT00000104491.2
    Conserved Domains (1) summary
    COG3142
    Location:26 → 256
    CutC; Copper homeostasis protein CutC [Inorganic ion transport and metabolism]

  4. XM_039084552.2 → XP_038940480.1  copper homeostasis protein cutC homolog isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZQP8
    Conserved Domains (1) summary
    COG3142
    Location:2 → 242
    CutC; Copper homeostasis protein CutC [Inorganic ion transport and metabolism]

RNA

  1. XR_005489132.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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