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Nudt8 nudix hydrolase 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361692, updated on 27-Nov-2024

Summary

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Official Symbol
Nudt8provided by RGD
Official Full Name
nudix hydrolase 8provided by RGD
Primary source
RGD:1309040
See related
EnsemblRapid:ENSRNOG00000083053 AllianceGenome:RGD:1309040
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable coenzyme A diphosphatase activity; magnesium ion binding activity; and manganese ion binding activity. Predicted to be involved in nucleoside phosphate catabolic process. Predicted to be located in mitochondrion. Orthologous to human NUDT8 (nudix hydrolase 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 852.2), Muscle (RPKM 226.0) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nudt8 in Genome Data Viewer
Location:
1q43
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210723209..210724717)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201293660..201295233)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219247428..219249155)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 3 family, member B2 like 1 Neighboring gene aldehyde dehydrogenase 3 family, member B2 Neighboring gene aminoacylase 3 Neighboring gene T-box transcription factor 10 Neighboring gene double C2-like domains, gamma Neighboring gene uncharacterized LOC134483955 Neighboring gene NADH:ubiquinone oxidoreductase core subunit V1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables coenzyme A diphosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables coenzyme A diphosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acetyl-CoA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in acetyl-CoA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in butyryl-CoA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in butyryl-CoA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in coenzyme A catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in coenzyme A catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in malonyl-CoA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in malonyl-CoA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in medium-chain fatty-acyl-CoA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in medium-chain fatty-acyl-CoA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in propionyl-CoA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in propionyl-CoA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in succinyl-CoA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in succinyl-CoA catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial coenzyme A diphosphatase NUDT8
Names
nucleoside diphosphate-linked moiety X motif 8, mitochondrial
nudix (nucleoside diphosphate linked moiety X)-type motif 8
NP_001387779.1
XP_008758411.1
XP_063124199.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001400850.1 → NP_001387779.1  mitochondrial coenzyme A diphosphatase NUDT8

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6HYQ7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    210723209..210724717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008760189.4 → XP_008758411.1  mitochondrial coenzyme A diphosphatase NUDT8 isoform X2

    See identical proteins and their annotated locations for XP_008758411.1

    UniProtKB/TrEMBL
    D3ZEH6
    Related
    ENSRNOP00000100071.1, ENSRNOT00000129621.1
    Conserved Domains (1) summary
    cd03426
    Location:31 → 201
    CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

  2. XM_063268129.1 → XP_063124199.1  mitochondrial coenzyme A diphosphatase NUDT8 isoform X1

    Related
    ENSRNOP00000108088.1, ENSRNOT00000163976.1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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