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Nap1l4 nucleosome assembly protein 1-like 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361684, updated on 2-Nov-2024

Summary

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Official Symbol
Nap1l4provided by RGD
Official Full Name
nucleosome assembly protein 1-like 4provided by RGD
Primary source
RGD:1305391
See related
EnsemblRapid:ENSRNOG00000020615 AllianceGenome:RGD:1305391
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable histone binding activity and nucleosome binding activity. Predicted to be involved in nucleosome assembly. Located in dendrite and neuronal cell body. Orthologous to human NAP1L4 (nucleosome assembly protein 1 like 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 571.3), Heart (RPKM 541.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nap1l4 in Genome Data Viewer
Location:
1q42
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (208139105..208175597, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (198709697..198746093, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (216715352..216751742, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 22, member 18 Neighboring gene pleckstrin homology-like domain, family A, member 2 Neighboring gene small nucleolar RNA, H/ACA box 54 Neighboring gene cysteinyl-tRNA synthetase 1 Neighboring gene uncharacterized LOC134483952 Neighboring gene transfer RNA valine (anticodon AAC) 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cellular expression and localization of DGKζ-interacting NAP1-like proteins in the brain and functional implications under hypoxic stress. Takahashi N, et al. Histochem Cell Biol, 2014 Nov. PMID 24893663
  2. Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone. Rodriguez P, et al. Genomics, 1997 Sep 15. PMID 9325046
  3. Histone Variant H2A.L.2 Guides Transition Protein-Dependent Protamine Assembly in Male Germ Cells. Barral S, et al. Mol Cell, 2017 Apr 6. PMID 28366643
  4. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
  5. Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons. Benleulmi-Chaachoua A, et al. J Pineal Res, 2016 Jan. PMID 26514267

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleosome binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleosome binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleosome binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
nucleosome assembly protein 1-like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012170.1 → NP_001012170.1  nucleosome assembly protein 1-like 4

    See identical proteins and their annotated locations for NP_001012170.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085801
    UniProtKB/Swiss-Prot
    Q5U2Z3
    UniProtKB/TrEMBL
    A0A8L2RA59, A6HYC3
    Related
    ENSRNOP00000051745.5, ENSRNOT00000054862.6
    Conserved Domains (1) summary
    pfam00956
    Location:67 → 337
    NAP; Nucleosome assembly protein (NAP)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    208139105..208175597 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230823.5 → XP_006230885.1  nucleosome assembly protein 1-like 4 isoform X1

    See identical proteins and their annotated locations for XP_006230885.1

    UniProtKB/Swiss-Prot
    Q5U2Z3
    UniProtKB/TrEMBL
    A0A8L2RA59, A6HYC3
    Conserved Domains (1) summary
    pfam00956
    Location:67 → 337
    NAP; Nucleosome assembly protein (NAP)

  2. XM_006230824.5 → XP_006230886.1  nucleosome assembly protein 1-like 4 isoform X1

    See identical proteins and their annotated locations for XP_006230886.1

    UniProtKB/Swiss-Prot
    Q5U2Z3
    UniProtKB/TrEMBL
    A0A8L2RA59, A6HYC3
    Conserved Domains (1) summary
    pfam00956
    Location:67 → 337
    NAP; Nucleosome assembly protein (NAP)

  3. XM_063268048.1 → XP_063124118.1  nucleosome assembly protein 1-like 4 isoform X1

    UniProtKB/Swiss-Prot
    Q5U2Z3
    UniProtKB/TrEMBL
    A6HYC3
    Related
    ENSRNOP00000093428.2, ENSRNOT00000102937.2

  4. XM_063268066.1 → XP_063124136.1  nucleosome assembly protein 1-like 4 isoform X1

    UniProtKB/Swiss-Prot
    Q5U2Z3
    UniProtKB/TrEMBL
    A6HYC3

  5. XM_063268072.1 → XP_063124142.1  nucleosome assembly protein 1-like 4 isoform X1

    UniProtKB/Swiss-Prot
    Q5U2Z3
    UniProtKB/TrEMBL
    A6HYC3

  6. XM_063268061.1 → XP_063124131.1  nucleosome assembly protein 1-like 4 isoform X1

    UniProtKB/Swiss-Prot
    Q5U2Z3
    UniProtKB/TrEMBL
    A6HYC3

  7. XM_063268046.1 → XP_063124116.1  nucleosome assembly protein 1-like 4 isoform X1

    UniProtKB/Swiss-Prot
    Q5U2Z3
    UniProtKB/TrEMBL
    A6HYC3

  8. XM_063268053.1 → XP_063124123.1  nucleosome assembly protein 1-like 4 isoform X1

    UniProtKB/Swiss-Prot
    Q5U2Z3
    UniProtKB/TrEMBL
    A6HYC3

  9. XM_063268082.1 → XP_063124152.1  nucleosome assembly protein 1-like 4 isoform X2

    UniProtKB/TrEMBL
    A0A0H2UHZ2, A6HYC4

  10. XM_063268091.1 → XP_063124161.1  nucleosome assembly protein 1-like 4 isoform X2

    UniProtKB/TrEMBL
    A0A0H2UHZ2, A6HYC4

  11. XM_063268100.1 → XP_063124170.1  nucleosome assembly protein 1-like 4 isoform X2

    UniProtKB/TrEMBL
    A0A0H2UHZ2, A6HYC4
    Related
    ENSRNOP00000075200.3, ENSRNOT00000087961.3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U2Z3.1 GenPept UniProtKB/Swiss-Prot:Q5U2Z3

Gene LinkOut

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