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Eef1akmt2 EEF1A lysine methyltransferase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361664, updated on 27-Nov-2024

Summary

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Official Symbol
Eef1akmt2provided by RGD
Official Full Name
EEF1A lysine methyltransferase 2provided by RGD
Primary source
RGD:1306300
See related
EnsemblRapid:ENSRNOG00000017137 AllianceGenome:RGD:1306300
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mettl10; RGD1306300
Summary
Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in peptidyl-lysine methylation. Predicted to be located in cytosol and nucleoplasm. Orthologous to human EEF1AKMT2 (EEF1A lysine methyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 77.6), Brain (RPKM 76.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Eef1akmt2 in Genome Data Viewer
Location:
1q41
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (197009919..197071033, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (187616156..187640934, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (204830008..204855627, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene phospholysine phosphohistidine inorganic pyrophosphate phosphatase Neighboring gene uncharacterized LOC120099945 Neighboring gene family with sequence similarity 53, member B Neighboring gene uncharacterized LOC134483949 Neighboring gene uncharacterized LOC102552031 Neighboring gene abraxas 2, BRISC complex subunit Neighboring gene ribosomal protein S23, pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Selenium-based S-adenosylmethionine analog reveals the mammalian seven-beta-strand methyltransferase METTL10 to be an EF1A1 lysine methyltransferase. Shimazu T, et al. PLoS One, 2014. PMID 25144183, Free PMC Article
  2. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-lysine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-lysine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-lysine methylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
EEF1A lysine methyltransferase 2
Names
methyltransferase like 10
methyltransferase-like protein 10
protein-lysine N-methyltransferase METTL10
NP_001380625.1
XP_017444917.1
XP_017444919.1
XP_038939222.1
XP_038939225.1
XP_038939232.1
XP_038939237.1
XP_063123985.1
XP_063123990.1
XP_063124004.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393696.1 → NP_001380625.1  EEF1A lysine methyltransferase 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6HX02, D4A7N2
    Related
    ENSRNOP00000023121.5, ENSRNOT00000023121.6
    Conserved Domains (1) summary
    pfam13847
    Location:80 → 214
    Methyltransf_31; Methyltransferase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    197009919..197071033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083309.1 → XP_038939237.1  EEF1A lysine methyltransferase 2 isoform X8

    UniProtKB/TrEMBL
    A0A0G2JVV2, A0A8I5ZLB6
    Related
    ENSRNOP00000110990.1, ENSRNOT00000134056.1

  2. XM_039083294.2 → XP_038939222.1  EEF1A lysine methyltransferase 2 isoform X2

  3. XM_039083297.2 → XP_038939225.1  EEF1A lysine methyltransferase 2 isoform X5

    Conserved Domains (1) summary
    pfam13649
    Location:83 → 127
    Methyltransf_25; Methyltransferase domain

  4. XM_039083304.1 → XP_038939232.1  EEF1A lysine methyltransferase 2 isoform X6

  5. XM_017589428.3 → XP_017444917.1  EEF1A lysine methyltransferase 2 isoform X1

  6. XM_063267934.1 → XP_063124004.1  EEF1A lysine methyltransferase 2 isoform X7

  7. XM_063267915.1 → XP_063123985.1  EEF1A lysine methyltransferase 2 isoform X3

  8. XM_017589430.3 → XP_017444919.1  EEF1A lysine methyltransferase 2 isoform X3

    Conserved Domains (1) summary
    pfam13847
    Location:16 → 150
    Methyltransf_31; Methyltransferase domain

  9. XM_063267920.1 → XP_063123990.1  EEF1A lysine methyltransferase 2 isoform X4

RNA

  1. XR_010054815.1 RNA Sequence

  2. XR_350777.5 RNA Sequence

  3. XR_005488872.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108504.1: Suppressed sequence

    Description
    NM_001108504.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
Nucleotide Protein Strain
Heading Accession and Version

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