polyph polyphemus [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: polyphprovided by FlyBase
Official Full Name: polyphemusprovided by FlyBase
Primary source: FLYBASE:FBgn0033572
Locus tag: Dmel_CG12943
See related: AllianceGenome:FB:FBgn0033572
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12943; Dmel\CG12943
Summary: Predicted to enable L-amino acid transmembrane transporter activity. Involved in defense response to bacterium and phagocytosis. Located in extracellular space. Is expressed in adult abdomen; adult head; and adult thorax. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to several human genes including SLC36A1 (solute carrier family 36 member 1); SLC36A2 (solute carrier family 36 member 2); and SLC36A3 (solute carrier family 36 member 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (10903570..10905563)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (6791075..6793068)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

CG12943 protein plays an important role regulating amino acid transport and reactive oxygen species production.
Title: A glutamate-dependent redox system in blood cells is integral for phagocytosis in Drosophila melanogaster.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables amino acid transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in amino acid transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in amino acid transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sexual reproduction	HEP more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	HDA more info	PubMed
is_active_in vacuolar membrane	IBA Inferred from Biological aspect of Ancestor more info

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain