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Fes FES proto-oncogene, tyrosine kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 361597, updated on 27-Nov-2024

Summary

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Official Symbol
Fesprovided by RGD
Official Full Name
FES proto-oncogene, tyrosine kinaseprovided by RGD
Primary source
RGD:1564385
See related
EnsemblRapid:ENSRNOG00000011683 AllianceGenome:RGD:1564385
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564385
Summary
Predicted to enable several functions, including immunoglobulin receptor binding activity; microtubule binding activity; and non-membrane spanning protein tyrosine kinase activity. Involved in cardiac muscle cell proliferation and myoblast proliferation. Predicted to be located in several cellular components, including cytoplasmic side of plasma membrane; focal adhesion; and microtubule cytoskeleton. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human FES (FES proto-oncogene, tyrosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 71.6), Spleen (RPKM 64.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fes in Genome Data Viewer
Location:
1q31
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (143746945..143756181, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (134337698..134346934, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (142174648..142183884, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L35A like 7 Neighboring gene HD domain containing 3 Neighboring gene mannosidase, alpha, class 2A, member 2 Neighboring gene uncharacterized LOC102553801 Neighboring gene furin (paired basic amino acid cleaving enzyme) Neighboring gene uncharacterized LOC134483745 Neighboring gene uncharacterized LOC108349447

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Epigenomic profiling of DNA methylation for hepatocellular carcinoma diagnosis and prognosis prediction. Zhang C, et al. J Gastroenterol Hepatol, 2019 Oct. PMID 31038805
  2. Prognostic CpG methylation biomarkers identified by methylation array in esophageal squamous cell carcinoma patients. Kuo IY, et al. Int J Med Sci, 2014. PMID 24936140, Free PMC Article
  3. K562 leukemia cells transfected with the human c-fes gene acquire the ability to undergo myeloid differentiation. Yu G, et al. J Biol Chem, 1989 Jun 15. PMID 2656706
  4. Regulation of the human c-fes protein tyrosine kinase (p93c-fes) by its src homology 2 domain and major autophosphorylation site (Tyr-713). Hjermstad SJ, et al. Oncogene, 1993 Aug. PMID 7687763
  5. Subcellular localization analysis of the closely related Fps/Fes and Fer protein-tyrosine kinases suggests a distinct role for Fps/Fes in vesicular trafficking. Zirngibl R, et al. Exp Cell Res, 2001 May 15. PMID 11339827

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A 95 kDa Fes protein was purified from the rat brain CRMP-CRAM complex and shown to be involved in Sema3A signaling [Fes].
    Title: Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling.
  2. Fes and Bcr cooperate to activate Rho family GTPases as part of a novel pathway regulating neurite extension in PC12 cells, and provide more evidence for an emerging role for Fes in neuronal differentiation.
    Title: The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables immunoglobulin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cardiac muscle cell proliferation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to vitamin D ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within centrosome cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule bundle formation ISO
Inferred from Sequence Orthology
more info
  
involved_in myoblast proliferation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of monocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell motility ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mast cell degranulation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tyrosine-protein kinase Fes/Fps
Names
feline sarcoma oncogene
NP_001101958.1
XP_038938259.1
XP_063123003.1
XP_063123011.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108488.1 → NP_001101958.1  tyrosine-protein kinase Fes/Fps

    See identical proteins and their annotated locations for NP_001101958.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473980
    UniProtKB/TrEMBL
    A0A8I5ZWJ2, A6JCB2, D4A584
    Related
    ENSRNOP00000016032.5, ENSRNOT00000016032.7
    Conserved Domains (4) summary
    cd07685
    Location:7 → 239
    F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
    cd10361
    Location:453 → 537
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    pfam07714
    Location:561 → 814
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:564 → 815
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    143746945..143756181 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266933.1 → XP_063123003.1  tyrosine-protein kinase Fes/Fps isoform X1

  2. XM_039082331.2 → XP_038938259.1  tyrosine-protein kinase Fes/Fps isoform X2

    Conserved Domains (2) summary
    cd07685
    Location:7 → 239
    F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
    cd10361
    Location:453 → 513
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

  3. XM_063266941.1 → XP_063123011.1  tyrosine-protein kinase Fes/Fps isoform X3

    UniProtKB/TrEMBL
    B2GV16

RNA

  1. XR_350521.5 RNA Sequence

  2. XR_005488133.2 RNA Sequence

  3. XR_005488136.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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