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Vrk3 VRK serine/threonine kinase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361565, updated on 4-Jan-2025

Summary

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Official Symbol
Vrk3provided by RGD
Official Full Name
VRK serine/threonine kinase 3provided by RGD
Primary source
RGD:1549692
See related
EnsemblRapid:ENSRNOG00000026517 AllianceGenome:RGD:1549692
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein phosphatase activator activity; protein phosphatase binding activity; and protein serine/threonine kinase activity. Predicted to be involved in DNA damage response; signal transduction; and skeletal muscle tissue development. Predicted to act upstream of or within negative regulation of ERK1 and ERK2 cascade. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human VRK3 (VRK serine/threonine kinase 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 139.3), Spleen (RPKM 120.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Vrk3 in Genome Data Viewer
Location:
1q22
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104379903..104407278)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95243344..95270780)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (100755622..100783008)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene IZUMO family member 2 Neighboring gene zinc finger protein 473 Neighboring gene activating transcription factor 5 Neighboring gene nucleoporin 62 Neighboring gene interleukin 4 induced 1 Neighboring gene TBC1 domain family, member 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. VRK3-mediated inactivation of ERK signaling in adult and embryonic rodent tissues. Kang TH, et al. Biochim Biophys Acta, 2008 Jan. PMID 18035061
  2. Characterization of three paralogous members of the Mammalian vaccinia related kinase family. Nichols RJ, et al. J Biol Chem, 2004 Feb 27. PMID 14645249
  3. Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip. Quiel A, et al. Biosens Bioelectron, 2012 Jun-Jul. PMID 22572157
  4. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC93929

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inactive serine/threonine-protein kinase VRK3
Names
serine/threonine-protein kinase VRK3
vaccinia related kinase 3
NP_001005561.2
XP_063122703.1
XP_063122707.1
XP_063122713.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005561.2 → NP_001005561.2  inactive serine/threonine-protein kinase VRK3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    F7F2H0, Q66HC2
    Related
    ENSRNOP00000076854.1, ENSRNOT00000108442.2
    Conserved Domains (4) summary
    COG0515
    Location:229 → 458
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    pfam12773
    Location:14 → 38
    DZR; Double zinc ribbon
    pfam13240
    Location:13 → 35
    zinc_ribbon_2; zinc-ribbon domain
    cl21453
    Location:143 → 445
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    104379903..104407278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266643.1 → XP_063122713.1  inactive serine/threonine-protein kinase VRK3 isoform X2

    UniProtKB/TrEMBL
    Q66HC2

  2. XM_063266637.1 → XP_063122707.1  inactive serine/threonine-protein kinase VRK3 isoform X1

    UniProtKB/TrEMBL
    F7F2H0, Q66HC2

  3. XM_063266633.1 → XP_063122703.1  inactive serine/threonine-protein kinase VRK3 isoform X1

    UniProtKB/TrEMBL
    F7F2H0, Q66HC2
    Related
    ENSRNOP00000081238.2, ENSRNOT00000104717.2

RNA

  1. XR_350316.5 RNA Sequence

  2. XR_350318.3 RNA Sequence

  3. XR_350317.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Chemical Information
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