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Etv2 ETS variant transcription factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361544, updated on 27-Nov-2024

Summary

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Official Symbol
Etv2provided by RGD
Official Full Name
ETS variant transcription factor 2provided by RGD
Primary source
RGD:1310603
See related
EnsemblRapid:ENSRNOG00000024288 AllianceGenome:RGD:1310603
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Etsrp71
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of endothelial cell differentiation; and positive regulation of macromolecule biosynthetic process. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in limb ischemia. Orthologous to human ETV2 (ETS variant transcription factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 10.2) See more
Orthologs
human mouse all
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Genomic context

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See Etv2 in Genome Data Viewer
Location:
1q21
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (95017980..95021582, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85890562..85894025, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89091239..89094570, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uroplakin 1A Neighboring gene cytochrome c oxidase subunit 6B1 Neighboring gene RNA binding motif protein 42 Neighboring gene RIKEN cDNA 2200002J24 gene like Neighboring gene HAUS augmin-like complex, subunit 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Etv2- and Fli1-Induced Vascular Progenitor Cells Enhance Functional Recovery in Ischemic Vascular Disease Model-Brief Report. Park SY, et al. Arterioscler Thromb Vasc Biol, 2020 Apr. PMID 32075417
  2. Adventitial Sca1+ Cells Transduced With ETV2 Are Committed to the Endothelial Fate and Improve Vascular Remodeling After Injury. Le Bras A, et al. Arterioscler Thromb Vasc Biol, 2018 Jan. PMID 29191922, Free PMC Article
  3. Extracellular vesicles of ETV2 transfected fibroblasts stimulate endothelial cells and improve neovascularization in a murine model of hindlimb ischemia. Van Pham P, et al. Cytotechnology, 2017 Oct. PMID 28466428, Free PMC Article
  4. ETV-2 activated proliferation of endothelial cells and attenuated acute hindlimb ischemia in mice. Van Pham P, et al. In Vitro Cell Dev Biol Anim, 2017 Aug. PMID 28424975
  5. Injury-Mediated Vascular Regeneration Requires Endothelial ER71/ETV2. Park C, et al. Arterioscler Thromb Vasc Biol, 2016 Jan. PMID 26586661, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within blastocyst development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hemopoiesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mesoderm formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within placenta development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of mesoderm development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ETS translocation variant 2
Names
ets related protein 71
ets variant gene 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427588.1 → NP_001414517.1  ETS translocation variant 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    Related
    ENSRNOP00000112163.1, ENSRNOT00000143716.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    95017980..95021582 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093962.2 → XP_038949890.1  ETS translocation variant 2 isoform X1

    UniProtKB/TrEMBL
    A6JA05
    Conserved Domains (1) summary
    smart00413
    Location:266 → 348
    ETS; erythroblast transformation specific domain

  2. XM_039093960.2 → XP_038949888.1  ETS translocation variant 2 isoform X1

    UniProtKB/TrEMBL
    A6JA05
    Conserved Domains (1) summary
    smart00413
    Location:266 → 348
    ETS; erythroblast transformation specific domain

  3. XM_063266487.1 → XP_063122557.1  ETS translocation variant 2 isoform X1

  4. XM_039093961.2 → XP_038949889.1  ETS translocation variant 2 isoform X1

    UniProtKB/TrEMBL
    A6JA05
    Conserved Domains (1) summary
    smart00413
    Location:266 → 348
    ETS; erythroblast transformation specific domain

  5. XM_039093958.2 → XP_038949886.1  ETS translocation variant 2 isoform X1

    UniProtKB/TrEMBL
    A6JA05
    Conserved Domains (1) summary
    smart00413
    Location:266 → 348
    ETS; erythroblast transformation specific domain

  6. XM_017590045.3 → XP_017445534.1  ETS translocation variant 2 isoform X3

    UniProtKB/TrEMBL
    A6JA05
    Conserved Domains (1) summary
    smart00413
    Location:233 → 315
    ETS; erythroblast transformation specific domain

  7. XM_006228814.4 → XP_006228876.1  ETS translocation variant 2 isoform X2

    See identical proteins and their annotated locations for XP_006228876.1

    UniProtKB/TrEMBL
    A6JA05, D3ZEY9
    Related
    ENSRNOP00000036461.6, ENSRNOT00000031873.8
    Conserved Domains (1) summary
    smart00413
    Location:234 → 316
    ETS; erythroblast transformation specific domain

  8. XM_063266495.1 → XP_063122565.1  ETS translocation variant 2 isoform X2

    UniProtKB/TrEMBL
    D3ZEY9
Nucleotide Protein Strain
Heading Accession and Version

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