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Leng8 leukocyte receptor cluster member 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361506, updated on 27-Nov-2024

Summary

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Official Symbol
Leng8provided by RGD
Official Full Name
leukocyte receptor cluster member 8provided by RGD
Primary source
RGD:1306180
See related
EnsemblRapid:ENSRNOG00000018642 AllianceGenome:RGD:1306180
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be active in nucleus. Orthologous to human LENG8 (leukocyte receptor cluster member 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 215.6), Thymus (RPKM 207.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Leng8 in Genome Data Viewer
Location:
1q21
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (79113038..79124868, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (70040785..70052662, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (73722088..73734459, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin like receptor A5 Neighboring gene ornithine decarboxylase 1, pseudogene 7 Neighboring gene CDC42 effector protein 5 Neighboring gene leukocyte receptor cluster member 9 Neighboring gene tweety family member 1 Neighboring gene leukocyte-associated immunoglobulin-like receptor 1 Neighboring gene uncharacterized LOC134482886

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC112858

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leukocyte receptor cluster member 8
Names
leukocyte receptor cluster (LRC) member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037790.4 → NP_001032879.2  leukocyte receptor cluster member 8

    See identical proteins and their annotated locations for NP_001032879.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6KNJ5, D3ZX52
    Related
    ENSRNOP00000025338.5, ENSRNOT00000025338.9
    Conserved Domains (2) summary
    pfam03399
    Location:569 → 754
    SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
    pfam12346
    Location:464 → 550
    HJURP_mid; Holliday junction recognition protein-associated repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    79113038..79124868 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266341.1 → XP_063122411.1  leukocyte receptor cluster member 8 isoform X7

  2. XM_063266337.1 → XP_063122407.1  leukocyte receptor cluster member 8 isoform X4

    Related
    ENSRNOP00000101769.1, ENSRNOT00000148159.1

  3. XM_063266340.1 → XP_063122410.1  leukocyte receptor cluster member 8 isoform X6

  4. XM_006228220.4 → XP_006228282.1  leukocyte receptor cluster member 8 isoform X2

    Conserved Domains (3) summary
    pfam03399
    Location:549 → 734
    SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
    pfam09849
    Location:119 → 256
    DUF2076; Uncharacterized protein conserved in bacteria (DUF2076)
    pfam12346
    Location:444 → 530
    HJURP_mid; Holliday junction recognition protein-associated repeat

  5. XM_008758948.4 → XP_008757170.1  leukocyte receptor cluster member 8 isoform X5

    See identical proteins and their annotated locations for XP_008757170.1

    UniProtKB/TrEMBL
    A6KNJ4
    Conserved Domains (2) summary
    pfam03399
    Location:569 → 764
    SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
    pfam12346
    Location:464 → 550
    HJURP_mid; Holliday junction recognition protein-associated repeat

  6. XM_008758946.4 → XP_008757168.1  leukocyte receptor cluster member 8 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K0W4
    Related
    ENSRNOP00000071606.1, ENSRNOT00000077964.3
    Conserved Domains (2) summary
    pfam03399
    Location:586 → 781
    SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
    pfam12346
    Location:481 → 567
    HJURP_mid; Holliday junction recognition protein-associated repeat

  7. XM_006228218.4 → XP_006228280.1  leukocyte receptor cluster member 8 isoform X1

    See identical proteins and their annotated locations for XP_006228280.1

    UniProtKB/TrEMBL
    A0A8I6GKE0
    Related
    ENSRNOP00000093659.1, ENSRNOT00000111838.2
    Conserved Domains (2) summary
    pfam03399
    Location:586 → 771
    SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
    pfam12346
    Location:481 → 567
    HJURP_mid; Holliday junction recognition protein-associated repeat

  8. XM_063266339.1 → XP_063122409.1  leukocyte receptor cluster member 8 isoform X5

    UniProtKB/TrEMBL
    A6KNJ4

  9. XM_063266336.1 → XP_063122406.1  leukocyte receptor cluster member 8 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K0W4

  10. XM_006228219.5 → XP_006228281.1  leukocyte receptor cluster member 8 isoform X1

    See identical proteins and their annotated locations for XP_006228281.1

    UniProtKB/TrEMBL
    A0A8I6GKE0
    Conserved Domains (2) summary
    pfam03399
    Location:586 → 771
    SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
    pfam12346
    Location:481 → 567
    HJURP_mid; Holliday junction recognition protein-associated repeat
Nucleotide Protein Strain
Heading Accession and Version

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