Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mthfd1lprovided by RGD
Official Full Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-likeprovided by RGD
Primary source: RGD:1307311
See related: EnsemblRapid:ENSRNOG00000019582 AllianceGenome:RGD:1307311
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fthfsdc1
Summary: Predicted to enable ATP binding activity; formate-tetrahydrofolate ligase activity; and protein homodimerization activity. Predicted to be involved in carboxylic acid metabolic process and chordate embryonic development. Predicted to be active in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human MTHFD1L (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 101.1), Spleen (RPKM 91.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p11-q11

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (42849424..43038313)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (40443926..40632911)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (40529092..40719232)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables formate-tetrahydrofolate ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables formate-tetrahydrofolate ligase activity	ISO Inferred from Sequence Orthology more info
enables methylenetetrahydrofolate dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 10-formyltetrahydrofolate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in 10-formyltetrahydrofolate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in embryonic neurocranium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic viscerocranium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in folic acid-containing compound metabolic process	ISO Inferred from Sequence Orthology more info
involved_in formate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in tetrahydrofolate interconversion	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: monofunctional C1-tetrahydrofolate synthase, mitochondrial

Names: formyltetrahydrofolate synthetase domain containing 1

NP_001101932.2

EC 6.3.4.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108462.2 → NP_001101932.2 monofunctional C1-tetrahydrofolate synthase, mitochondrial

See identical proteins and their annotated locations for NP_001101932.2

Status: PROVISIONAL

Source sequence(s)

BC166462

UniProtKB/TrEMBL

A6KIK6, B2GUZ3

Related

ENSRNOP00000026564.5, ENSRNOT00000026564.8

Conserved Domains (4) summary

PLN02759
Location:351 → 977

PLN02759; Formate--tetrahydrofolate ligase

COG0190
Location:82 → 285

FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

pfam00763
Location:73 → 179

THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

cl21454
Location:192 → 334

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins