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Hsdl1 hydroxysteroid dehydrogenase like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361418, updated on 4-Jan-2025

Summary

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Official Symbol
Hsdl1provided by RGD
Official Full Name
hydroxysteroid dehydrogenase like 1provided by RGD
Primary source
RGD:1308433
See related
EnsemblRapid:ENSRNOG00000015576 AllianceGenome:RGD:1308433
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308433
Summary
Predicted to be located in intermediate filament cytoskeleton and intracellular membrane-bounded organelle. Predicted to be active in mitochondrion. Orthologous to human HSDL1 (hydroxysteroid dehydrogenase like 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 82.6), Brain (RPKM 75.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hsdl1 in Genome Data Viewer
Location:
19q12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (64524435..64540527, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (47615794..47631892, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (52209403..52225486, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene N-terminal EF-hand calcium binding protein 2 Neighboring gene solute carrier family 38, member 8 Neighboring gene membrane-bound transcription factor peptidase, site 1 Neighboring gene dynein, axonemal, assembly factor 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit A2, pseudogene 3 Neighboring gene TATA-box binding protein associated factor, RNA polymerase 1 subunit C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human and zebrafish hydroxysteroid dehydrogenase like 1 (HSDL1) proteins are inactive enzymes but conserved among species. Meier M, et al. Chem Biol Interact, 2009 Mar 16. PMID 19026618
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC114519

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables steroid dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables steroid dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in intermediate filament cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
inactive hydroxysteroid dehydrogenase-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024896.1 → NP_001020067.1  inactive hydroxysteroid dehydrogenase-like protein 1

    See identical proteins and their annotated locations for NP_001020067.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097457
    UniProtKB/Swiss-Prot
    Q4V8B7
    UniProtKB/TrEMBL
    A0A8L2UJL9, A6IZJ3
    Related
    ENSRNOP00000020860.6, ENSRNOT00000020859.7
    Conserved Domains (1) summary
    cd05356
    Location:67 → 309
    17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    64524435..64540527 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006255713.5 → XP_006255775.1  inactive hydroxysteroid dehydrogenase-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006255775.1

    UniProtKB/Swiss-Prot
    Q4V8B7
    UniProtKB/TrEMBL
    A0A8L2UJL9, A6IZJ3
    Conserved Domains (1) summary
    cd05356
    Location:67 → 309
    17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs

  2. XM_039097871.2 → XP_038953799.1  inactive hydroxysteroid dehydrogenase-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q4V8B7
    UniProtKB/TrEMBL
    A0A8L2UJL9, A6IZJ3
    Conserved Domains (1) summary
    cd05356
    Location:67 → 309
    17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4V8B7.1 GenPept UniProtKB/Swiss-Prot:Q4V8B7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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