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Fbxo15 F-box protein 15 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361354, updated on 4-Jan-2025

Summary

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Symbol
Fbxo15provided by RGD
Full Name
F-box protein 15provided by RGD
Primary source
RGD:1310628
See related
EnsemblRapid:ENSRNOG00000038225 AllianceGenome:RGD:1310628
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXO15 (F-box protein 15). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 43.3), Testes (RPKM 30.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fbxo15 in Genome Data Viewer
Location:
18q12.3
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (80594444..80909549)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (78319577..78634695)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (81785408..81882796)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482966 Neighboring gene polyglutamine binding protein 1, pseudogene 1 Neighboring gene uncharacterized LOC134482968 Neighboring gene translocase of inner mitochondrial membrane 21 Neighboring gene rho-related GTP-binding protein RhoG-like Neighboring gene ATP binding cassette subfamily G member 2, pseudogene 1 Neighboring gene neuropilin and tolloid like 1 Neighboring gene enolase 1, pseudogene 27

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Tokuzawa Y, et al. Mol Cell Biol, 2003 Apr. PMID 12665572, Free PMC Article
  2. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
F-box only protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395752.1 → NP_001382681.1  F-box only protein 15

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    D3Z8N7
    Related
    ENSRNOP00000055000.7, ENSRNOT00000058199.7
    Conserved Domains (1) summary
    smart00256
    Location:81 → 121
    FBOX; A Receptor for Ubiquitination Targets

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    80594444..80909549
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096992.2 → XP_038952920.1  F-box only protein 15 isoform X1

    UniProtKB/TrEMBL
    D3Z8N7
    Conserved Domains (1) summary
    pfam12937
    Location:92 → 136
    F-box-like

  2. XM_039096994.2 → XP_038952922.1  F-box only protein 15 isoform X3

    Conserved Domains (1) summary
    pfam12937
    Location:140 → 184
    F-box-like

  3. XM_039096998.2 → XP_038952926.1  F-box only protein 15 isoform X7

    Conserved Domains (1) summary
    pfam12937
    Location:140 → 184
    F-box-like

  4. XM_039096993.2 → XP_038952921.1  F-box only protein 15 isoform X2

    Conserved Domains (1) summary
    pfam12937
    Location:140 → 184
    F-box-like

  5. XM_063277485.1 → XP_063133555.1  F-box only protein 15 isoform X4

  6. XM_039096997.2 → XP_038952925.1  F-box only protein 15 isoform X6

    Conserved Domains (1) summary
    pfam12937
    Location:140 → 184
    F-box-like

  7. XM_039096996.2 → XP_038952924.1  F-box only protein 15 isoform X5

    UniProtKB/TrEMBL
    A6K5M6
    Related
    ENSRNOP00000098243.2, ENSRNOT00000120608.2
    Conserved Domains (1) summary
    pfam12937
    Location:2 → 42
    F-box-like

  8. XM_039096995.2 → XP_038952923.1  F-box only protein 15 isoform X5

    UniProtKB/TrEMBL
    A6K5M6
    Conserved Domains (1) summary
    pfam12937
    Location:2 → 42
    F-box-like

  9. XM_063277486.1 → XP_063133556.1  F-box only protein 15 isoform X8

    UniProtKB/TrEMBL
    M0RD43

RNA

  1. XR_005496060.2 RNA Sequence

  2. XR_005496061.2 RNA Sequence

  3. XR_005496062.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108436.1: Suppressed sequence

    Description
    NM_001108436.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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