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Arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361314, updated on 4-Jan-2025

Summary

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Official Symbol
Arap3provided by RGD
Official Full Name
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3provided by RGD
Primary source
RGD:1304938
See related
EnsemblRapid:ENSRNOG00000055527 AllianceGenome:RGD:1304938
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Centd3; Arap3-ps1; RGD1304938
Summary
Predicted to enable GTPase activator activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in regulation of actin cytoskeleton organization. Predicted to be active in cytoplasm. Orthologous to human ARAP3 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 249.5), Heart (RPKM 99.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arap3 in Genome Data Viewer
Location:
18p11
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (30058739..30085415, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (29806214..29834217, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (31112083..31138142, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene histone deacetylase 3 Neighboring gene FCH and double SH3 domains 1 Neighboring gene RELT-like 2 Neighboring gene uncharacterized LOC134483010 Neighboring gene uncharacterized LOC108348772

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner. I ST, et al. J Cell Sci, 2004 Dec 1. PMID 15546919
  2. Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. Krugmann S, et al. Mol Cell, 2002 Jan. PMID 11804589
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
Names
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3, pseudogene 1
centaurin, delta 3
dual-specificity Rho- and Arf-GTPase activating protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427276.1 → NP_001414205.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A0G2JUX2
    Related
    ENSRNOP00000076387.2, ENSRNOT00000113487.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    30058739..30085415 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097402.2 → XP_038953330.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JUX2
    Conserved Domains (8) summary
    cd09490
    Location:4 → 66
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    cd04385
    Location:907 → 1082
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:285 → 377
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:392 → 475
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13259
    Location:1211 → 1327
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17902
    Location:485 → 600
    ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
    cl17171
    Location:672 → 784
    PH-like; Pleckstrin homology-like domain
    cl28922
    Location:1114 → 1211
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  2. XM_039097405.2 → XP_038953333.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JUX2
    Related
    ENSRNOP00000107707.1, ENSRNOT00000157872.1
    Conserved Domains (8) summary
    cd09490
    Location:4 → 66
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    cd04385
    Location:907 → 1082
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:285 → 377
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:392 → 475
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13259
    Location:1211 → 1327
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17902
    Location:485 → 600
    ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
    cl17171
    Location:672 → 784
    PH-like; Pleckstrin homology-like domain
    cl28922
    Location:1114 → 1211
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  3. XM_039097404.2 → XP_038953332.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JUX2, A0A0G2JVX3, A6J3E4
    Related
    ENSRNOP00000069654.3, ENSRNOT00000080097.3
    Conserved Domains (8) summary
    cd09490
    Location:4 → 66
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    cd04385
    Location:906 → 1081
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:284 → 376
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:391 → 474
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13259
    Location:1210 → 1326
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17902
    Location:484 → 599
    ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
    cl17171
    Location:671 → 783
    PH-like; Pleckstrin homology-like domain
    cl28922
    Location:1113 → 1210
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  4. XM_039097403.2 → XP_038953331.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JUX2
    Related
    ENSRNOP00000069263.3, ENSRNOT00000084438.3
    Conserved Domains (8) summary
    cd09490
    Location:4 → 66
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    cd04385
    Location:907 → 1082
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:285 → 377
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:392 → 475
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13259
    Location:1211 → 1327
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17902
    Location:485 → 600
    ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
    cl17171
    Location:672 → 784
    PH-like; Pleckstrin homology-like domain
    cl28922
    Location:1114 → 1211
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  5. XM_063277465.1 → XP_063133535.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JUX2

  6. XM_063277466.1 → XP_063133536.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X4

  7. XM_039097406.2 → XP_038953334.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X5

    UniProtKB/TrEMBL
    A0A8I5XUU6, A6J3E5
    Conserved Domains (7) summary
    cd09490
    Location:4 → 66
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    cd04385
    Location:907 → 1082
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:285 → 377
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:392 → 475
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd17902
    Location:485 → 600
    ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
    cl17171
    Location:672 → 784
    PH-like; Pleckstrin homology-like domain
    cl28922
    Location:1114 → 1143
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
Nucleotide Protein Strain
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