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Mat1 Menage a trois 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36130, updated on 4-Jan-2025

Summary

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Official Symbol
Mat1provided by FlyBase
Official Full Name
Menage a trois 1provided by FlyBase
Primary source
FLYBASE:FBgn0024956
Locus tag
Dmel_CG7614
See related
AllianceGenome:FB:FBgn0024956
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AT-1; CG7614; Dmel\CG7614; MAT1
Summary
Predicted to enable zinc ion binding activity. Predicted to be involved in DNA repair; regulation of transcription by RNA polymerase II; and transcription initiation at RNA polymerase II promoter. Part of transcription factor TFIIH holo complex. Is expressed in organism. Orthologous to human MNAT1 (MNAT1 component of CDK activating kinase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Mat1 in Genome Data Viewer
Location:
47B9-47B9; 2-63 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10738617..10739829, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6626122..6627334, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Rab3 Neighboring gene Carbonic anhydrase 13 Neighboring gene D-amino acid oxidase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43605 Neighboring gene long non-coding RNA:CR44299

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Xpd/Ercc2 regulates CAK activity and mitotic progression. Chen J, et al. Nature, 2003 Jul 10. PMID 12853965
  2. T-loop phosphorylation stabilizes the CDK7-cyclin H-MAT1 complex in vivo and regulates its CTD kinase activity. Larochelle S, et al. EMBO J, 2001 Jul 16. PMID 11447116, Free PMC Article
  3. TFIIH trafficking and its nuclear assembly during early Drosophila embryo development. Aguilar-Fuentes J, et al. J Cell Sci, 2006 Sep 15. PMID 16940351
  4. Secrets of a double agent: CDK7 in cell-cycle control and transcription. Fisher RP. J Cell Sci, 2005 Nov 15. PMID 16280550
  5. Mms19 is a mitotic gene that permits Cdk7 to be fully active as a Cdk-activating kinase. Nag RN, et al. Development, 2018 Jan 25. PMID 29361561, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activator activity TAS
Traceable Author Statement
more info
 PubMed 
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription initiation at RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of carboxy-terminal domain protein kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIIH holo complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIH holo complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIH holo complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of transcription factor TFIIH holo complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
menage a trois 1
Names
CG7614-PA
Mat1-PA
menage a trois 1 ortholog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    10738617..10739829 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136761.3 → NP_610605.1  menage a trois 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610605.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KPG8, Q8SX08
    Related
    FBpp0087350
    Conserved Domains (4) summary
    TIGR00570
    Location:1 → 313
    cdk7; CDK-activating kinase assembly factor MAT1
    cl03951
    Location:66 → 175
    CDC37_N; Cdc37 N terminal kinase binding
    cl12057
    Location:127 → 215
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain
    cl17238
    Location:3 → 47
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KPG8 Q7KPG8
Q8SX08 Q8SX08

Gene LinkOut

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