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Rab3 Rab3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36127, updated on 9-Dec-2024

Summary

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Official Symbol
Rab3provided by FlyBase
Official Full Name
Rab3provided by FlyBase
Primary source
FLYBASE:FBgn0005586
Locus tag
Dmel_CG7576
See related
AllianceGenome:FB:FBgn0005586
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AAF58762; CG7576; dm-Rab3; Dmel\CG7576; DmRab3; drab3; dRab3; Drab3; DRab3; DRAB3; P25228; rab3; Rab3A
Summary
Enables GTP binding activity and magnesium ion binding activity. Involved in several processes, including cytoskeletal matrix organization at active zone; maintenance of presynaptic active zone structure; and regulation of neurotransmitter secretion. Located in presynaptic active zone. Colocalizes with synaptic vesicle. Is expressed in several structures, including brain; imaginal disc; mushroom body; sensory nervous system primordium; and synaptic neuropil domain. Orthologous to several human genes including RAB3A (RAB3A, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Rab3 in Genome Data Viewer
Location:
47B7-47B7; 2-63 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10721335..10729203, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6608840..6616708, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46229 Neighboring gene starry night Neighboring gene Carbonic anhydrase 13 Neighboring gene D-amino acid oxidase 1 Neighboring gene uncharacterized protein Neighboring gene Menage a trois 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. rab3A attachment to the synaptic vesicle membrane mediated by a conserved polyisoprenylated carboxy-terminal sequence. Johnston PA, et al. Neuron, 1991 Jul. PMID 1648935
  2. Quantitative super-resolution imaging of Bruchpilot distinguishes active zone states. Ehmann N, et al. Nat Commun, 2014 Aug 18. PMID 25130366, Free PMC Article
  3. Structures of Drosophila melanogaster Rab2 and Rab3 bound to GMPPNP. Lardong JA, et al. Acta Crystallogr F Struct Biol Commun, 2015 Jan 1. PMID 25615965, Free PMC Article
  4. Motor dysfunction in Drosophila melanogaster as a biomarker for developmental neurotoxicity. Cabrita A, et al. iScience, 2022 Jul 15. PMID 35769875, Free PMC Article
  5. Synaptic Vesicle Proteins and Active Zone Plasticity. Kittel RJ, et al. Front Synaptic Neurosci, 2016. PMID 27148040, Free PMC Article

See all (142) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study demonstrated that the Rab3-GEF Controls Active Zone Development at the Drosophila Neuromuscular Junction.
    Title: Rab3-GEF Controls Active Zone Development at the Drosophila Neuromuscular Junction.
  2. Findings suggest that Rab3 controls the distribution of active zone components via a vesicle docking mechanism that is consistent with standard Rab protein function.
    Title: Mutational Analysis of Rab3 Function for Controlling Active Zone Protein Composition at the Drosophila Neuromuscular Junction.
  3. High-resolution crystal structures of Drosophila Rab2 and Rab3 in complex with GMPPNP and magnesium.
    Title: Structures of Drosophila melanogaster Rab2 and Rab3 bound to GMPPNP.
  4. Rab3 regulates basal synaptic strength and short-term plasticity at the level of release probability at individual sites.
    Title: Optical quantal analysis of synaptic transmission in wild-type and rab3-mutant Drosophila motor axons.
  5. The data of this study defined roles for Rab3-GAP and Rab3 in synaptic homeostasis and uncover a mechanism, acting at a late stage of vesicle release, that opposes the progression of homeostatic plasticity.
    Title: Rab3-GAP controls the progression of synaptic homeostasis at a late stage of vesicle release.
  6. This study showed that the small GTPase Rab3 controls the protein composition and release probability of individual active zones at the Drosophila neuromuscular junction.
    Title: Rab3 dynamically controls protein composition at active zones.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables myosin V binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Rab protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cytoskeletal matrix organization at active zone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maintenance of presynaptic active zone structure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neurotransmitter secretion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of short-term neuronal synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of synaptic vesicle fusion to presynaptic active zone membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in symbiont entry into host cell HMP PubMed 
involved_in vesicle-mediated transport IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in vesicle-mediated transport NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with presynaptic active zone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in presynaptic active zone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse HDA PubMed 
located_in synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in synaptic vesicle HDA PubMed 
colocalizes_with synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle NAS
Non-traceable Author Statement
more info
 PubMed 
located_in vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Rab3
Names
CG7576-PA
CG7576-PB
Rab-protein 3
Rab3-PA
Rab3-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    10721335..10729203 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078963.3 → NP_523687.1  Rab3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523687.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P25228, Q9V5N9
    UniProtKB/TrEMBL
    A0A4P7VAW6
    Related
    FBpp0087352
    Conserved Domains (1) summary
    cd01865
    Location:21 → 185
    Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D

  2. NM_001370044.1 → NP_001356961.1  Rab3, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P25228, Q9V5N9
    UniProtKB/TrEMBL
    A0A4P7VAW6
    Conserved Domains (1) summary
    cd01865
    Location:21 → 185
    Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A4P7VAW6 A0A4P7VAW6
P25228.1 P25228

Gene LinkOut

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