U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Akr1c15 aldo-keto reductase family 1, member C15 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361267, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Akr1c15provided by RGD
Official Full Name
aldo-keto reductase family 1, member C15provided by RGD
Primary source
RGD:1307514
See related
EnsemblRapid:ENSRNOG00000021735 AllianceGenome:RGD:1307514
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RAKc; Akr1cl; Akr1cl1; 17beta-HSD
Summary
Enables aldo-keto reductase (NADPH) activity. Predicted to be involved in prostaglandin biosynthetic process and steroid metabolic process. Located in cytoplasm. Orthologous to human AKR1C8 (aldo-keto reductase family 1 member C8). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 2564.6), Heart (RPKM 1516.1) and 4 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Akr1c15 in Genome Data Viewer
Location:
17q12.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (71091398..71117985, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (66181493..66208090, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (69835338..69862093, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1, member C3 Neighboring gene aldo-keto reductase family 1, member C14 Neighboring gene uncharacterized LOC120097737 Neighboring gene urocortin 3 Neighboring gene tubulin, alpha-like 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Enzymatic characteristics of an aldo-keto reductase family protein (AKR1C15) and its localization in rat tissues. Endo S, et al. Arch Biochem Biophys, 2007 Sep 1. PMID 17574202
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aldo-keto reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aldose reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables farnesol dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables ketosteroid monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables steroid dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in prostaglandin biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in steroid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
aldo-keto reductase family 1 member C15
Names
aldo-keto reductase family 1, member C-like 1
NP_001103370.1
XP_038951850.1
XP_063132700.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109900.1 → NP_001103370.1  aldo-keto reductase family 1 member C15

    See identical proteins and their annotated locations for NP_001103370.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473990
    UniProtKB/Swiss-Prot
    D3ZF77
    UniProtKB/TrEMBL
    A0A387KC71
    Related
    ENSRNOP00000055113.2, ENSRNOT00000058312.5
    Conserved Domains (1) summary
    COG0656
    Location:9 → 306
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    71091398..71117985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095922.2 → XP_038951850.1  aldo-keto reductase family 1 member C15 isoform X2

    Conserved Domains (1) summary
    cl00470
    Location:7 → 191
    AKR_SF; Aldo-keto reductase (AKR) superfamily

  2. XM_063276630.1 → XP_063132700.1  aldo-keto reductase family 1 member C15 isoform X1

RNA

  1. XR_010058904.1 RNA Sequence

  2. XR_005495305.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZF77.1 GenPept UniProtKB/Swiss-Prot:D3ZF77

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools