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Akr1c13 aldo-keto reductase family 1, member C13 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361266, updated on 27-Nov-2024

Summary

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Official Symbol
Akr1c13provided by RGD
Official Full Name
aldo-keto reductase family 1, member C13provided by RGD
Primary source
RGD:1308232
See related
EnsemblRapid:ENSRNOG00000062679 AllianceGenome:RGD:1308232
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Akr1c12; Akr1c12T
Summary
Predicted to enable aldose reductase (NADPH) activity; ketosteroid monooxygenase activity; and steroid dehydrogenase activity. Predicted to be involved in steroid metabolic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8. Orthologous to human AKR1C4 (aldo-keto reductase family 1 member C4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 416.4), Kidney (RPKM 179.5) and 1 other tissue See more
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Genomic context

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See Akr1c13 in Genome Data Viewer
Location:
17q12.2
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (70874110..70907518)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (65964186..65997598)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (69614323..69647772)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1, member C12-like 1 Neighboring gene voltage-dependent anion channel 1, pseudogene 6 Neighboring gene uncharacterized LOC134482872 Neighboring gene aldo-keto reductase family 1, member C19 Neighboring gene aldo-keto reductase family 1, member C12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aldose reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables androsterone dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables bile acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ketosteroid monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in daunorubicin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in doxorubicin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in progesterone metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in prostaglandin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
aldo-keto reductase family 1, member C12
Names
aldo-keto reductase family 1, member C12 temp

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170342.1 → NP_001163813.1  aldo-keto reductase family 1, member C12

    See identical proteins and their annotated locations for NP_001163813.1

    Status: VALIDATED

    Source sequence(s)
    CN542908, EX487988
    UniProtKB/TrEMBL
    D3ZPY8, Q2MHD9
    Related
    ENSRNOP00000037905.4, ENSRNOT00000029049.7
    Conserved Domains (2) summary
    COG0656
    Location:8 → 305
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:16 → 297
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    70874110..70907518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017600632.3 → XP_017456121.1  aldo-keto reductase family 1, member C12 isoform X2

    UniProtKB/TrEMBL
    Q2MHD9
    Conserved Domains (1) summary
    cd19108
    Location:36 → 315
    AKR_AKR1C1-35; AKR1C family of aldo-keto reductase (AKR)

  2. XM_006254190.5 → XP_006254252.1  aldo-keto reductase family 1, member C12 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AD50, Q2MHD9
    Related
    ENSRNOP00000089705.1, ENSRNOT00000102233.2
    Conserved Domains (2) summary
    COG0656
    Location:89 → 353
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:77 → 345
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

  3. XM_006254191.2 → XP_006254253.1  aldo-keto reductase family 1, member C12 isoform X3

    See identical proteins and their annotated locations for XP_006254253.1

    UniProtKB/TrEMBL
    D3ZPY8, Q2MHD9
    Conserved Domains (2) summary
    COG0656
    Location:8 → 305
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:16 → 297
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

  4. XM_008771874.3 → XP_008770096.1  aldo-keto reductase family 1, member C12 isoform X3

    See identical proteins and their annotated locations for XP_008770096.1

    UniProtKB/TrEMBL
    D3ZPY8, Q2MHD9
    Related
    ENSRNOP00000089272.2, ENSRNOT00000096532.2
    Conserved Domains (2) summary
    COG0656
    Location:8 → 305
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:16 → 297
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

  5. XM_039095920.2 → XP_038951848.1  aldo-keto reductase family 1, member C12 isoform X4

    Conserved Domains (1) summary
    cl00470
    Location:1 → 230
    AKR_SF; Aldo-keto reductase (AKR) superfamily

  6. XM_008771873.3 → XP_008770095.1  aldo-keto reductase family 1, member C12 isoform X3

    See identical proteins and their annotated locations for XP_008770095.1

    UniProtKB/TrEMBL
    D3ZPY8, Q2MHD9
    Conserved Domains (2) summary
    COG0656
    Location:8 → 305
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:16 → 297
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
Nucleotide Protein Strain
Heading Accession and Version

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