Eri1 exoribonuclease 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eri1provided by RGD
Official Full Name: exoribonuclease 1provided by RGD
Primary source: RGD:1308378
See related: EnsemblRapid:ENSRNOG00000011448 AllianceGenome:RGD:1308378
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Thex1; RGD1308378
Summary: Predicted to enable 3'-5'-RNA exonuclease activity; RNA binding activity; and ribosome binding activity. Predicted to be involved in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleus. Predicted to be part of histone pre-mRNA 3'end processing complex. Predicted to be active in cytoplasm and nucleolus. Orthologous to human ERI1 (exoribonuclease 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Thymus (RPKM 166.9), Spleen (RPKM 128.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (63427412..63447521)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (56724101..56744228)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (60307148..60327237)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH130811 (e-PCR)
- UniSTS:214095

D16Rat40 (e-PCR)
- UniSTS:118426

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3'-5' exonuclease activity	ISO Inferred from Sequence Orthology more info
enables 3'-5' exonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables 3'-5'-RNA exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3'-5'-RNA exonuclease activity	IEA Inferred from Electronic Annotation more info
enables histone pre-mRNA stem-loop binding	ISO Inferred from Sequence Orthology more info
enables histone pre-mRNA stem-loop binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables rRNA binding	ISO Inferred from Sequence Orthology more info
enables rRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info
enables ribosome binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in histone mRNA catabolic process	ISO Inferred from Sequence Orthology more info
NOT involved_in histone mRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in maturation of 5.8S rRNA	ISO Inferred from Sequence Orthology more info
involved_in rRNA 3'-end processing	ISO Inferred from Sequence Orthology more info
involved_in rRNA 3'-end processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
part_of histone pre-mRNA 3'end processing complex	ISO Inferred from Sequence Orthology more info
part_of histone pre-mRNA 3'end processing complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: 3'-5' exoribonuclease 1

Names: 3 ' exoribonuclease; 3' exoribonuclease; histone mRNA 3'-exonuclease 1; three prime histone mRNA exonuclease 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014143.1 → NP_001014165.1 3'-5' exoribonuclease 1

See identical proteins and their annotated locations for NP_001014165.1

Status: PROVISIONAL

Source sequence(s)

BC089828

UniProtKB/Swiss-Prot

Q5FVR4

UniProtKB/TrEMBL

A0A8I6AFW1, A6IVM7

Related

ENSRNOP00000015239.5, ENSRNOT00000015239.8

Conserved Domains (2) summary

cd06133
Location:126 → 306

ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

pfam02037
Location:72 → 106

SAP; SAP domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

63427412..63447521

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094644.2 → XP_038950572.1 3'-5' exoribonuclease 1 isoform X1

UniProtKB/TrEMBL

A0A8I6AFW1

Conserved Domains (2) summary

cd06133
Location:60 → 240

ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

pfam02037
Location:6 → 40

SAP; SAP domain