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Pef Peflin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36111, updated on 4-Jan-2025

Summary

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Official Symbol
Pefprovided by FlyBase
Official Full Name
Peflinprovided by FlyBase
Primary source
FLYBASE:FBgn0033529
Locus tag
Dmel_CG17765
See related
AllianceGenome:FB:FBgn0033529
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17765; Dmel\CG17765; pef; peflin
Summary
Predicted to enable calcium ion binding activity. Acts upstream of with a positive effect on retrograde trans-synaptic signaling. Is active in postsynaptic cytosol. Is expressed in several structures, including adult heart; anterior endoderm; anterior endoderm anlage; embryonic dorsal epidermis; and embryonic/larval midgut primordium. Orthologous to human PEF1 (penta-EF-hand domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Pef in Genome Data Viewer
Location:
47A11-47A11; 2-62 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10480163..10481886)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6367668..6369391)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45134 Neighboring gene withered Neighboring gene pre-lola-G Neighboring gene translin Neighboring gene longitudinals lacking Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling. Kikuma K, et al. Nat Commun, 2019 Jul 5. PMID 31278365, Free PMC Article
  2. Functional characterization of Drosophila Translin and Trax. Claussen M, et al. Genetics, 2006 Nov. PMID 17028328, Free PMC Article
  3. Synaptic homeostats: latent plasticity revealed at the Drosophila neuromuscular junction. Goel P, et al. Cell Mol Life Sci, 2021 Apr. PMID 33449150, Free PMC Article
  4. Mutations of the withered (whd) gene in Drosophila melanogaster confer hypersensitivity to oxidative stress and are lesions of the carnitine palmitoyltransferase I (CPT I) gene. Strub BR, et al. Genome, 2008 Jun. PMID 18521119
  5. Identification of genes expressed during Drosophila melanogaster gastrulation by using subtractive hybridization. González-Agüero M, et al. Gene, 2005 Jan 31. PMID 15716118

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_positive_effect retrograde trans-synaptic signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in postsynaptic cytosol IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

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Preferred Names
peflin
Names
CG17765-PA
Pef-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    10480163..10481886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136748.4 → NP_610592.1  peflin [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610592.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K2L7
    Related
    FBpp0087367
    Conserved Domains (3) summary
    COG5126
    Location:26 → 162
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:39 → 92
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl08302
    Location:105 → 159
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K2L7 Q7K2L7

Gene LinkOut

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