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whd withered [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36109, updated on 9-Dec-2024

Summary

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Official Symbol
whdprovided by FlyBase
Official Full Name
witheredprovided by FlyBase
Primary source
FLYBASE:FBgn0261862
Locus tag
Dmel_CG12891
See related
AllianceGenome:FB:FBgn0261862
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:GH27794; CG12891; cpt1; Cpt1; CPT1; CPTI; dCPT1; Dmel\CG12891; gh27794
Summary
Predicted to enable carnitine O-palmitoyltransferase activity. Involved in response to metal ion; response to oxidative stress; and response to starvation. Located in endomembrane system. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; fat body; and ganglia. Human ortholog(s) of this gene implicated in carnitine palmitoyltransferase I deficiency; hereditary spastic paraplegia 73; and lipid metabolism disorder. Orthologous to several human genes including CPT1A (carnitine palmitoyltransferase 1A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See whd in Genome Data Viewer
Location:
47A9-47A11; 2-62 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10469473..10478567, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6356978..6366072, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene G protein alpha subunit o Neighboring gene Cytochrome P450 49a1 Neighboring gene Chromatin assembly factor 1, p105 subunit Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45134 Neighboring gene translin Neighboring gene Peflin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Alternative exon usage in the single CPT1 gene of Drosophila generates functional diversity in the kinetic properties of the enzyme: differential expression of alternatively spliced variants in Drosophila tissues. Price NT, et al. J Biol Chem, 2010 Mar 12. PMID 20061394, Free PMC Article
  2. Sequencing and functional expression of the malonyl-CoA-sensitive carnitine palmitoyltransferase from Drosophila melanogaster. Jackson VN, et al. Biochem J, 1999 Aug 1. PMID 10417309, Free PMC Article
  3. Glial β-oxidation regulates Drosophila energy metabolism. Schulz JG, et al. Sci Rep, 2015 Jan 15. PMID 25588812, Free PMC Article
  4. Transportin-serine/arginine-rich (Tnpo-SR) proteins are necessary for proper lipid storage in the Drosophila fat body. Nagle C, et al. Biochem Biophys Res Commun, 2022 Mar 12. PMID 35104661
  5. Medium-Chain Fatty Acids, Beta-Hydroxybutyric Acid and Genetic Modulation of the Carnitine Shuttle Are Protective in a Drosophila Model of ALS Based on TDP-43. Manzo E, et al. Front Mol Neurosci, 2018. PMID 29904341, Free PMC Article

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. alternative splicing that specifically affects a structurally crucial region of the protein is an important mechanism through which functional diversity of CPT1 kinetics is generated from the single gene that occurs in insects
    Title: Alternative exon usage in the single CPT1 gene of Drosophila generates functional diversity in the kinetic properties of the enzyme: differential expression of alternatively spliced variants in Drosophila tissues.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables carnitine O-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carnitine O-palmitoyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in carnitine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of fatty acid beta-oxidation TAS
Traceable Author Statement
more info
 PubMed 
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 
is_active_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
withered
Names
CG12891-PA
CG12891-PB
CG12891-PC
CG12891-PD
carnitin-palmitoyl transferase-I
carnitine PalmitoylTransferase 1
carnitine-O-palmitoyltransferase
mitochondrial carnitine palamitoyltransferase I
mitochondrial carnitine palmitoyltransferase I
whd-PA
whd-PB
whd-PC
whd-PD
NP_001163111.1
NP_001163112.1
NP_523685.2
NP_724940.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    10469473..10478567 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078961.4 → NP_523685.2  withered, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523685.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JQH9
    Related
    FBpp0087399
    Conserved Domains (2) summary
    pfam00755
    Location:171 → 757
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
    pfam16484
    Location:1 → 45
    CPT_N; Carnitine O-palmitoyltransferase N-terminus

  2. NM_001169640.2 → NP_001163111.1  withered, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163111.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3K9
    Conserved Domains (2) summary
    pfam00755
    Location:171 → 759
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
    pfam16484
    Location:1 → 45
    CPT_N; Carnitine O-palmitoyltransferase N-terminus

  3. NM_165777.3 → NP_724940.1  withered, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724940.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JQH9
    Related
    FBpp0087400
    Conserved Domains (2) summary
    pfam00755
    Location:171 → 757
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
    pfam16484
    Location:1 → 45
    CPT_N; Carnitine O-palmitoyltransferase N-terminus

  4. NM_001169641.2 → NP_001163112.1  withered, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163112.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3K9
    Conserved Domains (2) summary
    pfam00755
    Location:171 → 759
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
    pfam16484
    Location:1 → 45
    CPT_N; Carnitine O-palmitoyltransferase N-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JQH9 Q7JQH9
Q9V3K9 Q9V3K9

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