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Ska3 spindle and kinetochore associated complex subunit 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361047, updated on 27-Nov-2024

Summary

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Official Symbol
Ska3provided by RGD
Official Full Name
spindle and kinetochore associated complex subunit 3provided by RGD
Primary source
RGD:1307201
See related
EnsemblRapid:ENSRNOG00000021847 AllianceGenome:RGD:1307201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307201
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in establishment of meiotic spindle orientation; nuclear chromosome segregation; and regulation of organelle organization. Predicted to be located in centrosome; cytosol; and mitotic spindle. Predicted to be part of SKA complex. Predicted to be active in kinetochore and spindle microtubule. Orthologous to human SKA3 (spindle and kinetochore associated complex subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 79.2), Spleen (RPKM 55.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ska3 in Genome Data Viewer
Location:
15p12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (36067372..36086563, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (31951812..31971010, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (38077903..38097100, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482228 Neighboring gene Sin3A associated protein 18 Neighboring gene mitochondrial ribosomal protein L57 Neighboring gene zinc finger DHHC-type palmitoyltransferase 20 Neighboring gene uncharacterized LOC134482124 Neighboring gene mitochondrial calcium uptake 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motility. Welburn JP, et al. Dev Cell, 2009 Mar. PMID 19289083, Free PMC Article
  2. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. Ohta S, et al. Cell, 2010 Sep 3. PMID 20813266, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore IEA
Inferred from Electronic Annotation
more info
  
involved_in attachment of mitotic spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
  
involved_in attachment of mitotic spindle microtubules to kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of meiotic spindle orientation IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of meiotic spindle orientation ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of meiotic spindle orientation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic metaphase chromosome alignment ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic sister chromatid segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic sister chromatid segregation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of mitotic spindle assembly checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of mitotic spindle assembly checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mitotic spindle assembly checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of microtubule polymerization or depolymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of microtubule polymerization or depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microtubule polymerization or depolymerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spindle assembly involved in female meiosis IEA
Inferred from Electronic Annotation
more info
  
involved_in spindle assembly involved in female meiosis ISO
Inferred from Sequence Orthology
more info
  
involved_in spindle assembly involved in female meiosis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of SKA complex IEA
Inferred from Electronic Annotation
more info
  
part_of SKA complex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in meiotic spindle IEA
Inferred from Electronic Annotation
more info
  
located_in meiotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of outer kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of outer kinetochore IEA
Inferred from Electronic Annotation
more info
  
part_of outer kinetochore ISO
Inferred from Sequence Orthology
more info
  
part_of outer kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in spindle microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in spindle microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
SKA complex subunit 3; spindle and kinetochore-associated protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108379.3 → NP_001101849.1  SKA complex subunit 3 isoform 2

    See identical proteins and their annotated locations for NP_001101849.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/Swiss-Prot
    A6KHD2, B2GUZ2
    UniProtKB/TrEMBL
    A0A8I5Y7E4, A0A8L2QHE9
    Related
    ENSRNOP00000077309.1, ENSRNOT00000117004.2
    Conserved Domains (1) summary
    cd12957
    Location:3 → 101
    SKA3_N; Spindle and kinetochore-associated protein 3, N-terminal domain

  2. NM_001431685.1 → NP_001418614.1  SKA complex subunit 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015

  3. NM_001431688.1 → NP_001418617.1  SKA complex subunit 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015

  4. NM_001431690.1 → NP_001418619.1  SKA complex subunit 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/Swiss-Prot
    A6KHD2, B2GUZ2
    UniProtKB/TrEMBL
    A0A8L2QHE9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    36067372..36086563 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006252074.3 → XP_006252136.1  spindle and kinetochore-associated protein 3 isoform X1

    Related
    ENSRNOP00000033626.6, ENSRNOT00000032723.6
    Conserved Domains (1) summary
    cd12957
    Location:3 → 102
    SKA3_N; Spindle and kinetochore-associated protein 3, N-terminal domain

  2. XM_006252075.3 → XP_006252137.1  spindle and kinetochore-associated protein 3 isoform X1

    Conserved Domains (1) summary
    cd12957
    Location:3 → 102
    SKA3_N; Spindle and kinetochore-associated protein 3, N-terminal domain

  3. XM_063274410.1 → XP_063130480.1  spindle and kinetochore-associated protein 3 isoform X2

  4. XM_063274411.1 → XP_063130481.1  spindle and kinetochore-associated protein 3 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2GUZ2.2 GenPept UniProtKB/Swiss-Prot:B2GUZ2

Gene LinkOut

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