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Arhgef40 Rho guanine nucleotide exchange factor 40 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361034, updated on 27-Nov-2024

Summary

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Official Symbol
Arhgef40provided by RGD
Official Full Name
Rho guanine nucleotide exchange factor 40provided by RGD
Primary source
RGD:1308093
See related
EnsemblRapid:ENSRNOG00000052354 AllianceGenome:RGD:1308093
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308093
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in cytosol and plasma membrane. Orthologous to human ARHGEF40 (Rho guanine nucleotide exchange factor 40). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 279.6), Heart (RPKM 102.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arhgef40 in Genome Data Viewer
Location:
15p14
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (27146155..27170012)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (24672645..24696510)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (28377916..28403090)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ribonuclease A family member 13 Neighboring gene small nuclear ribonucleoprotein polypeptide C, pseudogene 7 Neighboring gene zinc finger protein 219 Neighboring gene transmembrane protein 253 Neighboring gene ribosomal protein L31 like 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 40
Names
Rho guanine nucleotide exchange factor (GEF) 40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271313.1 → NP_001258242.1  rho guanine nucleotide exchange factor 40

    See identical proteins and their annotated locations for NP_001258242.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A0G2JZE7, A0A8I5ZUE2
    Related
    ENSRNOP00000082140.2, ENSRNOT00000104210.2
    Conserved Domains (4) summary
    cd13242
    Location:1241 → 1376
    PH_puratrophin-1; Puratrophin-1 pleckstrin homology (PH) domain
    pfam00169
    Location:1266 → 1364
    PH; PH domain
    cl02488
    Location:789 → 967
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl02571
    Location:1083 → 1242
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    27146155..27170012
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093480.2 → XP_038949408.1  rho guanine nucleotide exchange factor 40 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZRN9
    Conserved Domains (3) summary
    PHA03247
    Location:251 → 446
    PHA03247; large tegument protein UL36; Provisional
    cl02488
    Location:789 → 967
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl02571
    Location:1083 → 1242
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  2. XM_039093478.2 → XP_038949406.1  rho guanine nucleotide exchange factor 40 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZUE2
    Conserved Domains (4) summary
    PHA03247
    Location:251 → 446
    PHA03247; large tegument protein UL36; Provisional
    cd13242
    Location:1241 → 1376
    PH_puratrophin-1; Puratrophin-1 pleckstrin homology (PH) domain
    cl02488
    Location:789 → 967
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl02571
    Location:1083 → 1242
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  3. XM_063274402.1 → XP_063130472.1  rho guanine nucleotide exchange factor 40 isoform X3

    UniProtKB/TrEMBL
    A0A8I6ARU3

  4. XM_039093479.2 → XP_038949407.1  rho guanine nucleotide exchange factor 40 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZRN9, A0A8I6ARU3
    Related
    ENSRNOP00000096089.1, ENSRNOT00000108540.2
    Conserved Domains (4) summary
    PHA03247
    Location:251 → 446
    PHA03247; large tegument protein UL36; Provisional
    cd13242
    Location:1241 → 1376
    PH_puratrophin-1; Puratrophin-1 pleckstrin homology (PH) domain
    cl02488
    Location:789 → 967
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl02571
    Location:1083 → 1242
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  5. XM_039093477.2 → XP_038949405.1  rho guanine nucleotide exchange factor 40 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZUE2
    Conserved Domains (4) summary
    PHA03247
    Location:251 → 446
    PHA03247; large tegument protein UL36; Provisional
    cd13242
    Location:1241 → 1376
    PH_puratrophin-1; Puratrophin-1 pleckstrin homology (PH) domain
    cl02488
    Location:789 → 967
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl02571
    Location:1083 → 1242
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  6. XM_039093476.2 → XP_038949404.1  rho guanine nucleotide exchange factor 40 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZUE2
    Conserved Domains (4) summary
    PHA03247
    Location:251 → 446
    PHA03247; large tegument protein UL36; Provisional
    cd13242
    Location:1241 → 1376
    PH_puratrophin-1; Puratrophin-1 pleckstrin homology (PH) domain
    cl02488
    Location:789 → 967
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl02571
    Location:1083 → 1242
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  7. XM_063274401.1 → XP_063130471.1  rho guanine nucleotide exchange factor 40 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JZE7

  8. XM_063274400.1 → XP_063130470.1  rho guanine nucleotide exchange factor 40 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JZE7

RNA

  1. XR_010057835.1 RNA Sequence

  2. XR_005493755.2 RNA Sequence

  3. XR_010057836.1 RNA Sequence

  4. XR_001841260.3 RNA Sequence

  5. XR_010057837.1 RNA Sequence

  6. XR_010057838.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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