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RanBPM Ran-binding protein M [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36102, updated on 4-Jan-2025

Summary

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Official Symbol
RanBPMprovided by FlyBase
Official Full Name
Ran-binding protein Mprovided by FlyBase
Primary source
FLYBASE:FBgn0262114
Locus tag
Dmel_CG42236
See related
AllianceGenome:FB:FBgn0262114
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11763; CG42236; Dmel\CG42236; l(2)k05201
Old locus tag
Dmel_CG11763
Summary
Predicted to enable small GTPase binding activity. Involved in several processes, including dorsal appendage formation; follicle cell of egg chamber-cell adhesion; and germ-line stem-cell niche homeostasis. Located in cytoplasm; membrane; and nucleus. Part of GID complex. Is expressed in several structures, including adult head; germline cell; larval ventral nerve cord; ovary; and somatic cell of ovariole. Orthologous to several human genes including RANBP9 (RAN binding protein 9). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See RanBPM in Genome Data Viewer
Location:
47A7-47A7; 2-62 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10429708..10436581)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6317213..6324086)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Peroxiredoxin 6b Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene G protein alpha subunit o Neighboring gene Cytochrome P450 49a1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila gene RanBPM functions in the mushroom body to regulate larval behavior. Scantlebury N, et al. PLoS One, 2010 May 14. PMID 20498842, Free PMC Article
  2. RanBPM regulates cell shape, arrangement, and capacity of the female germline stem cell niche in Drosophila melanogaster. Dansereau DA, et al. J Cell Biol, 2008 Sep 8. PMID 18762575, Free PMC Article
  3. The E2 Marie Kondo and the CTLH E3 ligase clear deposited RNA binding proteins during the maternal-to-zygotic transition. Zavortink M, et al. Elife, 2020 Jun 23. PMID 32573431, Free PMC Article
  4. Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila. Baeg GH, et al. Genes Dev, 2005 Aug 15. PMID 16055650, Free PMC Article
  5. dCas9-targeted locus-specific protein isolation method identifies histone gene regulators. Tsui C, et al. Proc Natl Acad Sci U S A, 2018 Mar 20. PMID 29507191, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables small GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dorsal appendage formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in follicle cell of egg chamber-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ-line stem-cell niche homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in larval feeding behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of GID complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Ran-binding protein M
Names
CG42236-PA
CG42236-PC
CG42236-PD
CG42236-PE
CG42236-PF
CG42236-PG
Ran binding protein M
Ran-Binding protein in the microtubule organizing center
Ran-binding proteins 9/10 homologue
RanBPM-PA
RanBPM-PC
RanBPM-PD
RanBPM-PE
RanBPM-PF
RanBPM-PG
lethal (2) k05201

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    10429708..10436581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165770.3 → NP_724932.1  Ran-binding protein M, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724932.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C4IY22
    Related
    FBpp0087358
    Conserved Domains (5) summary
    smart00668
    Location:655 → 711
    CTLH; C-terminal to LisH motif
    smart00757
    Location:846 → 944
    CRA; CT11-RanBPM
    pfam04554
    Location:55 → 103
    Extensin_2; Extensin-like region
    pfam10607
    Location:655 → 938
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    cd12909
    Location:442 → 584
    SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10

  2. NM_001316413.1 → NP_001303342.1  Ran-binding protein M, isoform G [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A126GUM4, C4IY22
    Conserved Domains (6) summary
    smart00668
    Location:655 → 711
    CTLH; C-terminal to LisH motif
    smart00757
    Location:846 → 944
    CRA; CT11-RanBPM
    pfam04554
    Location:55 → 103
    Extensin_2; Extensin-like region
    pfam06994
    Location:137 → 188
    Involucrin2; Involucrin
    pfam10607
    Location:655 → 938
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    cd12909
    Location:442 → 584
    SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10

  3. NM_001259326.1 → NP_001246255.1  Ran-binding protein M, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246255.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K851, C4IY22
    Conserved Domains (5) summary
    smart00668
    Location:656 → 712
    CTLH; C-terminal to LisH motif
    smart00757
    Location:847 → 945
    CRA; CT11-RanBPM
    pfam04554
    Location:55 → 103
    Extensin_2; Extensin-like region
    pfam10607
    Location:656 → 939
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    cd12909
    Location:442 → 585
    SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10

  4. NM_001038849.2 → NP_001033938.1  Ran-binding protein M, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001033938.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1Z895, A1Z896, A8E757, Q4Z8K6, Q6NN33, Q8T0U5, Q960F3
    UniProtKB/TrEMBL
    C4IY22
    Conserved Domains (5) summary
    smart00668
    Location:655 → 711
    CTLH; C-terminal to LisH motif
    smart00757
    Location:848 → 946
    CRA; CT11-RanBPM
    pfam04554
    Location:55 → 103
    Extensin_2; Extensin-like region
    pfam10607
    Location:655 → 940
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    cd12909
    Location:442 → 584
    SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10

  5. NM_136741.3 → NP_610585.2  Ran-binding protein M, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610585.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    X5D3H6
    Related
    FBpp0087357
    Conserved Domains (5) summary
    smart00667
    Location:256 → 279
    LisH; Lissencephaly type-1-like homology motif
    smart00668
    Location:293 → 349
    CTLH; C-terminal to LisH motif
    smart00757
    Location:484 → 582
    CRA; CT11-RanBPM
    pfam10607
    Location:293 → 576
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    cd12909
    Location:80 → 222
    SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10

  6. NM_001273938.1 → NP_001260867.1  Ran-binding protein M, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260867.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFL0
    Conserved Domains (5) summary
    smart00667
    Location:256 → 279
    LisH; Lissencephaly type-1-like homology motif
    smart00668
    Location:293 → 349
    CTLH; C-terminal to LisH motif
    smart00757
    Location:489 → 587
    CRA; CT11-RanBPM
    pfam10607
    Location:293 → 581
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    cd12909
    Location:80 → 222
    SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K851 A0A0B4K851
A0A0B4KFL0 A0A0B4KFL0
A0A126GUM4 A0A126GUM4
Q4Z8K6.1 Q4Z8K6

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