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Traf3ip3 TRAF3 interacting protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360900, updated on 27-Nov-2024

Summary

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Official Symbol
Traf3ip3provided by RGD
Official Full Name
TRAF3 interacting protein 3provided by RGD
Primary source
RGD:1304848
See related
EnsemblRapid:ENSRNOG00000005565 AllianceGenome:RGD:1304848
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1304848
Summary
Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in cytoplasmic pattern recognition receptor signaling pathway and positive regulation of type I interferon production. Predicted to act upstream of or within several processes, including antiviral innate immune response; cellular response to cytokine stimulus; and positive regulation of type I interferon production. Predicted to be active in mitochondrion. Orthologous to human TRAF3IP3 (TRAF3 interacting protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 277.9), Thymus (RPKM 258.1) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Traf3ip3 in Genome Data Viewer
Location:
13q27
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (107223499..107248358, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (104694802..104719655, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (111892744..111917368, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene UTP25 small subunit processome component Neighboring gene uncharacterized LOC120096360 Neighboring gene interferon regulatory factor 6 Neighboring gene similar to human chromosome 1 open reading frame 74 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene hydroxysteroid 11-beta dehydrogenase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC108851

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to interferon-alpha ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to interferon-beta ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic pattern recognition receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic pattern recognition receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of interferon-alpha production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
TRAF3-interacting JNK-activating modulator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014132.2 → NP_001014154.1  TRAF3-interacting JNK-activating modulator isoform 1

    See identical proteins and their annotated locations for NP_001014154.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A8I6AKZ2, A6JH23, F7FMH4, Q5FVQ1
    Related
    ENSRNOP00000007649.4, ENSRNOT00000007649.7
    Conserved Domains (1) summary
    TIGR02168
    Location:277 → 439
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. NM_001429806.1 → NP_001416735.1  TRAF3-interacting JNK-activating modulator isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    107223499..107248358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090944.2 → XP_038946872.1  TRAF3-interacting JNK-activating modulator isoform X1

    Conserved Domains (2) summary
    COG4372
    Location:216 → 438
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    cd21912
    Location:190 → 234
    CC1_T3JAM; first coiled-coil (CC1) domain found in TRAF3-interacting JNK-activating modulator

  2. XM_039090945.1 → XP_038946873.1  TRAF3-interacting JNK-activating modulator isoform X3

    Conserved Domains (1) summary
    COG4372
    Location:1 → 222
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

  3. XM_008769865.4 → XP_008768087.2  TRAF3-interacting JNK-activating modulator isoform X2

    Conserved Domains (2) summary
    COG4372
    Location:61 → 282
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    cd21912
    Location:35 → 79
    CC1_T3JAM; first coiled-coil (CC1) domain found in TRAF3-interacting JNK-activating modulator
Nucleotide Protein Strain
Heading Accession and Version

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