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Fbxo21 F-box protein 21 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360818, updated on 27-Nov-2024

Summary

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Official Symbol
Fbxo21provided by RGD
Official Full Name
F-box protein 21provided by RGD
Primary source
RGD:1307346
See related
EnsemblRapid:ENSRNOG00000001129 AllianceGenome:RGD:1307346
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA binding activity. Orthologous to human FBXO21 (F-box protein 21). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 214.8), Brain (RPKM 206.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fbxo21 in Genome Data Viewer
Location:
12q16
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (44231918..44266035, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (38570878..38605133, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (44244633..44279044, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene F-box and WD repeat domain containing 8 Neighboring gene uncharacterized LOC134481299 Neighboring gene tescalcin Neighboring gene uncharacterized LOC120095990 Neighboring gene uncharacterized LOC120095991 Neighboring gene nitric oxide synthase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. JUNB-FBXO21-ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy. Lin Z, et al. Aging Cell, 2021 Feb. PMID 33450132, Free PMC Article
  2. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
F-box only protein 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108338.3 → NP_001101808.2  F-box only protein 21

    Status: VALIDATED

    Source sequence(s)
    BC158866, CB582551, CB615901, CB715798, JAXUCZ010000012
    UniProtKB/TrEMBL
    A6J1M6
    Conserved Domains (2) summary
    TIGR02097
    Location:493 → 590
    yccV; hemimethylated DNA binding domain
    pfam13369
    Location:260 → 388
    Transglut_core2; Transglutaminase-like superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    44231918..44266035 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089601.2 → XP_038945529.1  F-box only protein 21 isoform X1

    UniProtKB/TrEMBL
    A6J1M6, F1M5Q6
    Related
    ENSRNOP00000059243.4, ENSRNOT00000064900.5
    Conserved Domains (2) summary
    TIGR02097
    Location:500 → 597
    yccV; hemimethylated DNA binding domain
    pfam13369
    Location:260 → 388
    Transglut_core2; Transglutaminase-like superfamily
Nucleotide Protein Strain
Heading Accession and Version

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