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Rhbdd2 rhomboid domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360793, updated on 4-Jan-2025

Summary

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Official Symbol
Rhbdd2provided by RGD
Official Full Name
rhomboid domain containing 2provided by RGD
Primary source
RGD:1308231
See related
EnsemblRapid:ENSRNOG00000001443 AllianceGenome:RGD:1308231
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rhbdl7
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be located in Golgi membrane; nucleoplasm; and perinuclear region of cytoplasm. Orthologous to human RHBDD2 (rhomboid domain containing 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 82.2), Kidney (RPKM 66.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rhbdd2 in Genome Data Viewer
Location:
12q12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (26680206..26690926, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (21043605..21054305, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (24091132..24102081, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 120A Neighboring gene cytochrome p450 oxidoreductase Neighboring gene C-C motif chemokine ligand 24 Neighboring gene C-C motif chemokine ligand 26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Dynamics of the rhomboid-like protein RHBDD2 expression in mouse retina and involvement of its human ortholog in retinitis pigmentosa. Ahmedli NB, et al. J Biol Chem, 2013 Apr 5. PMID 23386608, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rhomboid domain-containing protein 2
Names
rhomboid, veinlet-like 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191827.1 → NP_001178756.1  rhomboid domain-containing protein 2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    D3ZQG3
    Related
    ENSRNOP00000001962.5, ENSRNOT00000001962.8
    Conserved Domains (1) summary
    pfam01694
    Location:54 → 202
    Rhomboid; Rhomboid family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    26680206..26690926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249182.5 → XP_006249244.1  rhomboid domain-containing protein 2 isoform X1

    Conserved Domains (1) summary
    pfam03154
    Location:108 → 208
    Atrophin-1; Atrophin-1 family
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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