Zfp358 zinc finger protein 358 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zfp358provided by RGD
Official Full Name: zinc finger protein 358provided by RGD
Primary source: RGD:1310416
See related: AllianceGenome:RGD:1310416
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Orthologous to human ZNF358 (zinc finger protein 358). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Muscle (RPKM 40.3), Lung (RPKM 29.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12p12

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (6350266..6354359)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (1552367..1556460)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (2046472..2050565)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of immune system process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 358

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108328.1 → NP_001101798.1 zinc finger protein 358

See identical proteins and their annotated locations for NP_001101798.1

Status: PROVISIONAL

Source sequence(s)

CH474084

UniProtKB/TrEMBL

A6KQ05, D3ZRG3

Conserved Domains (5) summary

COG5048
Location:236 → 429

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:355 → 375

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:241 → 263

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:256 → 280

zf-H2C2_2; Zinc-finger double domain

pfam15909
Location:382 → 460

zf-C2H2_8; C2H2-type zinc ribbon