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Popdc2 popeye domain cAMP effector 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360718, updated on 27-Nov-2024

Summary

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Official Symbol
Popdc2provided by RGD
Official Full Name
popeye domain cAMP effector 2provided by RGD
Primary source
RGD:735226
See related
EnsemblRapid:ENSRNOG00000058752 AllianceGenome:RGD:735226
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cAMP binding activity. Predicted to be involved in several processes, including heart development; skeletal muscle tissue development; and striated muscle cell differentiation. Predicted to act upstream of or within regulation of heart rate and sinoatrial node cell development. Predicted to be located in membrane. Predicted to be active in sarcolemma. Orthologous to human POPDC2 (popeye domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 242.5), Muscle (RPKM 54.9) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Popdc2 in Genome Data Viewer
Location:
11q21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (75850068..75897094, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (62351843..62398688, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (64915041..64954704, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352341 Neighboring gene ADP-ribosylarginine hydrolase Neighboring gene phospholipase A1 member A Neighboring gene cytochrome c oxidase copper chaperone COX17 Neighboring gene cilia and flagella associated protein 91

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The Popdc gene family in the rat: molecular cloning, characterization and expression analysis in the heart and cultured cardiomyocytes. Parnes D, et al. Biochim Biophys Acta, 2007 Sep-Oct. PMID 17662479
  2. An interaction of heart disease-associated proteins POPDC1/2 with XIRP1 in transverse tubules and intercalated discs. Holt I, et al. BMC Mol Cell Biol, 2020 Dec 1. PMID 33261556, Free PMC Article
  3. POPDC1(S201F) causes muscular dystrophy and arrhythmia by affecting protein trafficking. Schindler RF, et al. J Clin Invest, 2016 Jan. PMID 26642364, Free PMC Article
  4. Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice. Froese A, et al. J Clin Invest, 2012 Mar. PMID 22354168, Free PMC Article
  5. Isolation and characterization of the novel popeye gene family expressed in skeletal muscle and heart. Andrée B, et al. Dev Biol, 2000 Jul 15. PMID 10882522

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An interaction of heart disease-associated proteins POPDC1/2 with XIRP1 in transverse tubules and intercalated discs.
    Title: An interaction of heart disease-associated proteins POPDC1/2 with XIRP1 in transverse tubules and intercalated discs.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC72601

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cAMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of heart rate ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sinoatrial node cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal muscle tissue development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in striated muscle cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
popeye domain-containing protein 2
Names
popeye domain containing 2
popeye domain-containing protein 2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199113.1 → NP_954544.1  popeye domain-containing protein 2

    See identical proteins and their annotated locations for NP_954544.1

    Status: PROVISIONAL

    Source sequence(s)
    BC061876
    UniProtKB/TrEMBL
    A0A8I6GG90, Q6P722
    Related
    ENSRNOP00000071721.1, ENSRNOT00000087892.3
    Conserved Domains (1) summary
    pfam04831
    Location:26 → 251
    Popeye; Popeye protein conserved region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    75850068..75897094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270640.1 → XP_063126710.1  popeye domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    Q6P722

  2. XM_008768734.4 → XP_008766956.1  popeye domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_008766956.1

    UniProtKB/TrEMBL
    A6IR71
    Related
    ENSRNOP00000087674.2, ENSRNOT00000095198.2
    Conserved Domains (1) summary
    pfam04831
    Location:26 → 308
    Popeye; Popeye protein conserved region

  3. XM_008768733.4 → XP_008766955.1  popeye domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_008766955.1

    UniProtKB/TrEMBL
    A6IR71
    Conserved Domains (1) summary
    pfam04831
    Location:26 → 308
    Popeye; Popeye protein conserved region

  4. XM_017598027.3 → XP_017453516.1  popeye domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A6IR71
    Conserved Domains (1) summary
    pfam04831
    Location:26 → 308
    Popeye; Popeye protein conserved region

  5. XM_063270639.1 → XP_063126709.1  popeye domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    Q6P722

  6. XM_039088491.2 → XP_038944419.1  popeye domain-containing protein 2 isoform X3

    Conserved Domains (1) summary
    pfam04831
    Location:25 → 202
    Popeye; Popeye protein conserved region

RNA

  1. XR_005491039.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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