Ifngr2 interferon gamma receptor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ifngr2provided by RGD
Official Full Name: interferon gamma receptor 2provided by RGD
Primary source: RGD:1307532
See related: EnsemblRapid:ENSRNOG00000002032 AllianceGenome:RGD:1307532
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable type II interferon receptor activity. Involved in microglial cell activation and positive regulation of NMDA glutamate receptor activity. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 28. Orthologous to human IFNGR2 (interferon gamma receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 110.9), Spleen (RPKM 87.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (44265703..44283975)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (30779733..30798005)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (31694339..31712611)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Ifngr2 (e-PCR), detects polymorphism
- UniSTS:259092

RH129605 (e-PCR)
- UniSTS:212904

RH129609 (e-PCR)
- UniSTS:212904

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables type II interferon receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in microglial cell activation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of NMDA glutamate receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in type II interferon-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in type III interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interferon gamma receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108313.1 → NP_001101783.1 interferon gamma receptor 2 precursor

See identical proteins and their annotated locations for NP_001101783.1

Status: PROVISIONAL

Source sequence(s)

CH473989

UniProtKB/TrEMBL

A6JLG1, D4A109

Related

ENSRNOP00000002779.5, ENSRNOT00000002779.7

Conserved Domains (1) summary

cl21522
Location:27 → 121

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...